Single Nucleotide Polymorphisms and the Likelihood of Prostate Cancer at a Given Prostate Specific Antigen Level

Stacy Loeb, H Ballentine Carter, Patrick Walsh, William B Isaacs, Anna Kettermann, Toshiko Tanaka, Luigi Ferrucci, E. Jeffrey Metter

Research output: Contribution to journalArticle

Abstract

Purpose: Prostate specific antigen is used for prostate cancer screening but its specificity is limited. Specificity might be increased by considering genotype associated prostate specific antigen levels. Materials and Methods: We examined associations between single nucleotide polymorphisms on chromosomes 10 and 19 (previously shown to be associated with prostate specific antigen) with prostate specific antigen and prostate cancer in 505 men from the Baltimore Longitudinal Study of Aging. Results: In a model with age and date the risk ratio for prostate cancer was 1.18 (95% CI 1.13-1.23) per unit increase in prostate specific antigen. Including the interaction between alleles and prostate specific antigen significantly altered the risk ratio for prostate cancer (Cox proportional hazards p

Original languageEnglish (US)
Pages (from-to)101-105
Number of pages5
JournalJournal of Urology
Volume182
Issue number1
DOIs
StatePublished - Jul 2009

Fingerprint

Prostate-Specific Antigen
Single Nucleotide Polymorphism
Prostatic Neoplasms
Odds Ratio
Chromosomes, Human, Pair 19
Chromosomes, Human, Pair 10
Baltimore
Early Detection of Cancer
Longitudinal Studies
Alleles
Genotype

Keywords

  • genetics
  • mass screening
  • polymorphism
  • prostate-specific antigen
  • prostatic neoplasms
  • single nucleotide

ASJC Scopus subject areas

  • Urology

Cite this

Single Nucleotide Polymorphisms and the Likelihood of Prostate Cancer at a Given Prostate Specific Antigen Level. / Loeb, Stacy; Carter, H Ballentine; Walsh, Patrick; Isaacs, William B; Kettermann, Anna; Tanaka, Toshiko; Ferrucci, Luigi; Metter, E. Jeffrey.

In: Journal of Urology, Vol. 182, No. 1, 07.2009, p. 101-105.

Research output: Contribution to journalArticle

Loeb, Stacy ; Carter, H Ballentine ; Walsh, Patrick ; Isaacs, William B ; Kettermann, Anna ; Tanaka, Toshiko ; Ferrucci, Luigi ; Metter, E. Jeffrey. / Single Nucleotide Polymorphisms and the Likelihood of Prostate Cancer at a Given Prostate Specific Antigen Level. In: Journal of Urology. 2009 ; Vol. 182, No. 1. pp. 101-105.
@article{5a97c53ed492444ea14a0d9c25f03568,
title = "Single Nucleotide Polymorphisms and the Likelihood of Prostate Cancer at a Given Prostate Specific Antigen Level",
abstract = "Purpose: Prostate specific antigen is used for prostate cancer screening but its specificity is limited. Specificity might be increased by considering genotype associated prostate specific antigen levels. Materials and Methods: We examined associations between single nucleotide polymorphisms on chromosomes 10 and 19 (previously shown to be associated with prostate specific antigen) with prostate specific antigen and prostate cancer in 505 men from the Baltimore Longitudinal Study of Aging. Results: In a model with age and date the risk ratio for prostate cancer was 1.18 (95{\%} CI 1.13-1.23) per unit increase in prostate specific antigen. Including the interaction between alleles and prostate specific antigen significantly altered the risk ratio for prostate cancer (Cox proportional hazards p",
keywords = "genetics, mass screening, polymorphism, prostate-specific antigen, prostatic neoplasms, single nucleotide",
author = "Stacy Loeb and Carter, {H Ballentine} and Patrick Walsh and Isaacs, {William B} and Anna Kettermann and Toshiko Tanaka and Luigi Ferrucci and Metter, {E. Jeffrey}",
year = "2009",
month = "7",
doi = "10.1016/j.juro.2009.02.126",
language = "English (US)",
volume = "182",
pages = "101--105",
journal = "Journal of Urology",
issn = "0022-5347",
publisher = "Elsevier Inc.",
number = "1",

}

TY - JOUR

T1 - Single Nucleotide Polymorphisms and the Likelihood of Prostate Cancer at a Given Prostate Specific Antigen Level

AU - Loeb, Stacy

AU - Carter, H Ballentine

AU - Walsh, Patrick

AU - Isaacs, William B

AU - Kettermann, Anna

AU - Tanaka, Toshiko

AU - Ferrucci, Luigi

AU - Metter, E. Jeffrey

PY - 2009/7

Y1 - 2009/7

N2 - Purpose: Prostate specific antigen is used for prostate cancer screening but its specificity is limited. Specificity might be increased by considering genotype associated prostate specific antigen levels. Materials and Methods: We examined associations between single nucleotide polymorphisms on chromosomes 10 and 19 (previously shown to be associated with prostate specific antigen) with prostate specific antigen and prostate cancer in 505 men from the Baltimore Longitudinal Study of Aging. Results: In a model with age and date the risk ratio for prostate cancer was 1.18 (95% CI 1.13-1.23) per unit increase in prostate specific antigen. Including the interaction between alleles and prostate specific antigen significantly altered the risk ratio for prostate cancer (Cox proportional hazards p

AB - Purpose: Prostate specific antigen is used for prostate cancer screening but its specificity is limited. Specificity might be increased by considering genotype associated prostate specific antigen levels. Materials and Methods: We examined associations between single nucleotide polymorphisms on chromosomes 10 and 19 (previously shown to be associated with prostate specific antigen) with prostate specific antigen and prostate cancer in 505 men from the Baltimore Longitudinal Study of Aging. Results: In a model with age and date the risk ratio for prostate cancer was 1.18 (95% CI 1.13-1.23) per unit increase in prostate specific antigen. Including the interaction between alleles and prostate specific antigen significantly altered the risk ratio for prostate cancer (Cox proportional hazards p

KW - genetics

KW - mass screening

KW - polymorphism

KW - prostate-specific antigen

KW - prostatic neoplasms

KW - single nucleotide

UR - http://www.scopus.com/inward/record.url?scp=67349141550&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67349141550&partnerID=8YFLogxK

U2 - 10.1016/j.juro.2009.02.126

DO - 10.1016/j.juro.2009.02.126

M3 - Article

VL - 182

SP - 101

EP - 105

JO - Journal of Urology

JF - Journal of Urology

SN - 0022-5347

IS - 1

ER -