@article{6a1cc888aca64b7bbfe6ccd97cd952dd,
title = "Single-neuron dynamics in human focal epilepsy",
abstract = "Epileptic seizures are traditionally characterized as the ultimate expression of monolithic, hypersynchronous neuronal activity arising from unbalanced runaway excitation. Here we report the first examination of spike train patterns in large ensembles of single neurons during seizures in persons with epilepsy. Contrary to the traditional view, neuronal spiking activity during seizure initiation and spread was highly heterogeneous, not hypersynchronous, suggesting complex interactions among different neuronal groups even at the spatial scale of small cortical patches. In contrast to earlier stages, seizure termination is a nearly homogenous phenomenon followed by an almost complete cessation of spiking across recorded neuronal ensembles. Notably, even neurons outside the region of seizure onset showed significant changes in activity minutes before the seizure. These findings suggest a revision of current thinking about seizure mechanisms and point to the possibility of seizure prevention based on spiking activity in neocortical neurons.",
author = "Wilson Truccolo and Donoghue, {Jacob A.} and Hochberg, {Leigh R.} and Eskandar, {Emad N.} and Madsen, {Joseph R.} and Anderson, {William S.} and Brown, {Emery N.} and Eric Halgren and Cash, {Sydney S.}",
note = "Funding Information: The authors thank the patients who participated in this study, as well as the nursing and physician staff at each facility. We also thank A.M. Chan, C.J. Keller, A. Dykstra and J.E. Cormier for technical assistance, and J.P. Donoghue and K.J. Staley for critical reading of the manuscript. This research is funded by a CIMIT grant and US National Institutes of Health (NIH) National Institute of Neurological Disorders and Stroke (NINDS) NS062092 to S.S.C.; an NIH–NINDS Career Award (5K01NS057389) to W.T.; NIH NS018741 to E.H.; NINDS K08NS066099-01A1 to W.S.A.; US National Eye Institute EY017658, US National Institute on Drug Abuse NS063249, US National Science Foundation IOB 0645886, Howard Hughes Medical Institute and the Klingenstein Foundation to E.N.E.; NIH Director{\textquoteright}s Pioneer Award DP1OD003646 to E.N.B.; US Department of Veterans Affairs Career Development Transition Award, Doris Duke Charitable Foundation–Clinical Scientist Development Award, Massachusetts General Hospital–Deane Institute for Integrated Research on Atrial Fibrillation and Stroke, and NIH-NIDCD R01DC009899 to L.R.H. The contents do not represent the views of the Department of Veterans Affairs or the United States government.",
year = "2011",
month = may,
doi = "10.1038/nn.2782",
language = "English (US)",
volume = "14",
pages = "635--643",
journal = "Nature neuroscience",
issn = "1097-6256",
publisher = "Nature Publishing Group",
number = "5",
}