Single molecule studies of cyclic peptides using molecular matrix at liquid/solid interface by scanning tunneling microscopy

Yibing Wang, Lin Niu, Yibao Li, Xiaobo Mao, Yanlian Yang, Chen Wang

Research output: Contribution to journalArticlepeer-review

Abstract

We report in this work the single molecule studies of cyclic peptide, cyclosporine A (CsA), using a molecular network formed by star-shaped oligofluorene (StOF-COOH3) at the liquid/solid interface by scanning tunneling microscopy (STM). Individual cyclosporine A can be identified and resolved in the molecular network, and the high-resolution STM images of CsA show polygon-like characteristics with a diameter of approximately 1.7 nm. Furthermore, the complex of CsA and Mg2+ has also been observed to adsorb inside of the molecular matrix. The STM results reveal two adsorption characteristics for the CsA-Mg2+ complex, which is suggestive of asymmetrical configurations of the complex. The difference in binding energy between the two observed adsorption configurations is estimated to be 1.88 kJ•mol-1. These results help set the stage for studying the fine structures and functions of various cyclic peptides at the liquid/solid interface.

Original languageEnglish (US)
Pages (from-to)16305-16311
Number of pages7
JournalLangmuir
Volume26
Issue number21
DOIs
StatePublished - Nov 2 2010
Externally publishedYes

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Spectroscopy
  • Electrochemistry

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