Single Magnetic Resonance Imaging vs Magnetic Resonance Imaging/Computed Tomography Planning in Cervical Cancer Brachytherapy

S. Beriwal, H. Kim, D. Coon, R. Mogus, D. E. Heron, X. Li, M. S. Huq

Research output: Contribution to journalArticlepeer-review


Aims: To compare differences in dose to the target volume and organs at risk (OARs) for ring and tandem brachytherapy using individualised magnetic resonance imaging (MRI)/computed tomography-based three-dimensional treatment plans for each application vs plans based on a single scan for all fractions. Materials and methods: The study was carried out in 10 patients with carcinoma of the uterine cervix, treated with external beam radiotherapy and five fractions of high dose rate brachytherapy. Planning was carried out using MRI for the first fraction and computed tomography for each of the four subsequent fractions. The MRI-based plan was taken as the reference and the single-plan procedure was calculated by using the weights from the reference plan to calculate the dose distribution for each subsequent computed tomography-based plan. The high-risk clinical target volume (HRCTV) and OARs were delineated as per GEC-ESTRO guidelines. Total doses from external beam radiotherapy and brachytherapy were summated and normalised to a 2 Gy fraction size. Results: The mean D90 for the HRCTV was 81.9 Gy when using one plan and 84 Gy when using individual treatment plans. Similarly, the mean D2cc was 75.68 Gy vs 74.99 Gy for the bladder, 55.84 Gy vs 56.56 Gy for the rectum and 64.8 Gy vs 65.5 Gy for the sigmoid. Ring rotation was identified in three patients, resulting in a change in dwell positions, which otherwise could have led to either a high bladder dose or suboptimal coverage of the HRCTV. Conclusions: Our study has shown that a single-plan procedure achieved acceptable dosimetry in most patients. However, the individualised plan improved dosimetry by accounting for variations in applicator geometry and the position of critical organs.

Original languageEnglish (US)
Pages (from-to)483-487
Number of pages5
JournalClinical Oncology
Issue number6
StatePublished - Aug 2009
Externally publishedYes


  • Cervix
  • computed tomography
  • dosimetry
  • high dose rate
  • magnetic resonance imaging
  • simulation

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging


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