The ventilation perfusion (V/Q) imbalances that occur when a single lung is transplanted into an emphysematous recipient have thought tought to be an inevitable result of the physiologic setting. To determine whether these V/Q imbalances are due mainly to the physiologic setting or to allograft rejection and other processes involving the transplant, papain emphysema was produced in the right lung of 25 dogs and documented by roentgenograms, pulmonary function tests, angiograms, V/Q scans, and histologic examination. The normal left lung of these animals was then autografted or allografted under immunosuppression. Serial scans, roentgenograms, and lung function tests were performed. After autografting and allografting, transplant perfusion and ventilation decreased transiently but usually returned to preoperative levels, with the transplant providing the majority of ventilation and perfusion and being washed out more effectively than the emphysematous lung. V/Q imbalances or hypoxemia did not occur when the transplants were radiographically normal, but were sometimes present when the transplants had roentgenologic infiltrates due to rejection or other processes. Thus, single lung transplantation in emphysema does not produce obligatory V/Q imbalances. These results help justify further cautious clinical trials with this procedure.
|Original language||English (US)|
|Number of pages||5|
|State||Published - 1975|
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