Single loop multi-gap resonator for whole body EPR imaging of mice at 1.2 GHz

Sergey Petryakov, Alexandre Samouilov, Eric Kesselring, Tomasz Wasowicz, George L. Caia, Jay L. Zweier

Research output: Contribution to journalArticlepeer-review

Abstract

For whole body EPR imaging of small animals, typically low frequencies of 250-750 MHz have been used due to the microwave losses at higher frequencies and the challenges in designing suitable resonators to accommodate these large lossy samples. However, low microwave frequency limits the obtainable sensitivity. L-band frequencies can provide higher sensitivity, and have been commonly used for localized in vivo EPR spectroscopy. Therefore, it would be highly desirable to develop an L-band microwave resonator suitable for in vivo whole body EPR imaging of small animals such as living mice. A 1.2 GHz 16-gap resonator with inner diameter of 42 mm and 48 mm length was designed and constructed for whole body EPR imaging of small animals. The resonator has good field homogeneity and stability to animal-induced motional noise. Resonator stability was achieved with electrical and mechanical design utilizing a fixed position double coupling loop of novel geometry, thus minimizing the number of moving parts. Using this resonator, high quality EPR images of lossy phantoms and living mice were obtained. This design provides good sensitivity, ease of sample access, excellent stability and uniform B1 field homogeneity for in vivo whole body EPR imaging of mice at 1.2 GHz.

Original languageEnglish (US)
Pages (from-to)68-73
Number of pages6
JournalJournal of Magnetic Resonance
Volume188
Issue number1
DOIs
StatePublished - Sep 2007
Externally publishedYes

Keywords

  • Electron paramagnetic resonance
  • Imaging
  • Resonator
  • Spectroscopy

ASJC Scopus subject areas

  • Molecular Biology
  • Physical and Theoretical Chemistry
  • Spectroscopy
  • Radiology Nuclear Medicine and imaging
  • Condensed Matter Physics

Fingerprint

Dive into the research topics of 'Single loop multi-gap resonator for whole body EPR imaging of mice at 1.2 GHz'. Together they form a unique fingerprint.

Cite this