Single-dose ceftriaxone versus 10 days of cefaclor for otitis media

J. M. Chamberlain, D. A. Boenning, Y. Waisman, Bruce Klein, B. L. Klein, J. Goldfarb, S. Medendorp

Research output: Contribution to journalArticle

Abstract

We conducted a controlled clinical trial to determine the efficacy of single-dose intramuscular ceftriaxone for the treatment of acute otitis media. Fifty-four children aged 18 months to 6 years with clinical and tympanometric evidence of otitis media were randomized to receive either 50 mg/kg ceftriaxone or 10 days of oral cefaclor 40 mg/kg/day. Resolution of symptoms and clinical and tympanometric appearance of the tympanic membrane at follow-up visits were used to determine outcome. Thirty-one children received ceftriaxone and 23 received oral cefaclor. There were no treatment failures. There were no significant differences between groups in persistence of effusion or recurrence of acute otitis media. We conclude that a single intramuscular dose of ceftriaxone compares favorably with 10 days of oral cefaclor for the treatment of acute otitis media.

Original languageEnglish (US)
Pages (from-to)642-646
Number of pages5
JournalClinical Pediatrics
Volume33
Issue number11
StatePublished - 1994
Externally publishedYes

Fingerprint

Cefaclor
Ceftriaxone
Otitis Media
Tympanic Membrane
Controlled Clinical Trials
Treatment Failure
Recurrence
Therapeutics

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Chamberlain, J. M., Boenning, D. A., Waisman, Y., Klein, B., Klein, B. L., Goldfarb, J., & Medendorp, S. (1994). Single-dose ceftriaxone versus 10 days of cefaclor for otitis media. Clinical Pediatrics, 33(11), 642-646.

Single-dose ceftriaxone versus 10 days of cefaclor for otitis media. / Chamberlain, J. M.; Boenning, D. A.; Waisman, Y.; Klein, Bruce; Klein, B. L.; Goldfarb, J.; Medendorp, S.

In: Clinical Pediatrics, Vol. 33, No. 11, 1994, p. 642-646.

Research output: Contribution to journalArticle

Chamberlain, JM, Boenning, DA, Waisman, Y, Klein, B, Klein, BL, Goldfarb, J & Medendorp, S 1994, 'Single-dose ceftriaxone versus 10 days of cefaclor for otitis media', Clinical Pediatrics, vol. 33, no. 11, pp. 642-646.
Chamberlain JM, Boenning DA, Waisman Y, Klein B, Klein BL, Goldfarb J et al. Single-dose ceftriaxone versus 10 days of cefaclor for otitis media. Clinical Pediatrics. 1994;33(11):642-646.
Chamberlain, J. M. ; Boenning, D. A. ; Waisman, Y. ; Klein, Bruce ; Klein, B. L. ; Goldfarb, J. ; Medendorp, S. / Single-dose ceftriaxone versus 10 days of cefaclor for otitis media. In: Clinical Pediatrics. 1994 ; Vol. 33, No. 11. pp. 642-646.
@article{5c8f6c7643d8471ba1fdb4e8976b844e,
title = "Single-dose ceftriaxone versus 10 days of cefaclor for otitis media",
abstract = "We conducted a controlled clinical trial to determine the efficacy of single-dose intramuscular ceftriaxone for the treatment of acute otitis media. Fifty-four children aged 18 months to 6 years with clinical and tympanometric evidence of otitis media were randomized to receive either 50 mg/kg ceftriaxone or 10 days of oral cefaclor 40 mg/kg/day. Resolution of symptoms and clinical and tympanometric appearance of the tympanic membrane at follow-up visits were used to determine outcome. Thirty-one children received ceftriaxone and 23 received oral cefaclor. There were no treatment failures. There were no significant differences between groups in persistence of effusion or recurrence of acute otitis media. We conclude that a single intramuscular dose of ceftriaxone compares favorably with 10 days of oral cefaclor for the treatment of acute otitis media.",
author = "Chamberlain, {J. M.} and Boenning, {D. A.} and Y. Waisman and Bruce Klein and Klein, {B. L.} and J. Goldfarb and S. Medendorp",
year = "1994",
language = "English (US)",
volume = "33",
pages = "642--646",
journal = "Clinical Pediatrics",
issn = "0009-9228",
publisher = "SAGE Publications Inc.",
number = "11",

}

TY - JOUR

T1 - Single-dose ceftriaxone versus 10 days of cefaclor for otitis media

AU - Chamberlain, J. M.

AU - Boenning, D. A.

AU - Waisman, Y.

AU - Klein, Bruce

AU - Klein, B. L.

AU - Goldfarb, J.

AU - Medendorp, S.

PY - 1994

Y1 - 1994

N2 - We conducted a controlled clinical trial to determine the efficacy of single-dose intramuscular ceftriaxone for the treatment of acute otitis media. Fifty-four children aged 18 months to 6 years with clinical and tympanometric evidence of otitis media were randomized to receive either 50 mg/kg ceftriaxone or 10 days of oral cefaclor 40 mg/kg/day. Resolution of symptoms and clinical and tympanometric appearance of the tympanic membrane at follow-up visits were used to determine outcome. Thirty-one children received ceftriaxone and 23 received oral cefaclor. There were no treatment failures. There were no significant differences between groups in persistence of effusion or recurrence of acute otitis media. We conclude that a single intramuscular dose of ceftriaxone compares favorably with 10 days of oral cefaclor for the treatment of acute otitis media.

AB - We conducted a controlled clinical trial to determine the efficacy of single-dose intramuscular ceftriaxone for the treatment of acute otitis media. Fifty-four children aged 18 months to 6 years with clinical and tympanometric evidence of otitis media were randomized to receive either 50 mg/kg ceftriaxone or 10 days of oral cefaclor 40 mg/kg/day. Resolution of symptoms and clinical and tympanometric appearance of the tympanic membrane at follow-up visits were used to determine outcome. Thirty-one children received ceftriaxone and 23 received oral cefaclor. There were no treatment failures. There were no significant differences between groups in persistence of effusion or recurrence of acute otitis media. We conclude that a single intramuscular dose of ceftriaxone compares favorably with 10 days of oral cefaclor for the treatment of acute otitis media.

UR - http://www.scopus.com/inward/record.url?scp=0028046585&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028046585&partnerID=8YFLogxK

M3 - Article

C2 - 7859421

AN - SCOPUS:0028046585

VL - 33

SP - 642

EP - 646

JO - Clinical Pediatrics

JF - Clinical Pediatrics

SN - 0009-9228

IS - 11

ER -