Abstract
A single 2-g dose of ampicillin or a placebo identical in appearance was administered intravenously in a randomized, prospective, double-blind manner to 71 patients undergoing cesarean section. The solutions were given either on call to the operating room or during the intraoperative period. Postoperative morbidity from infection occurred in 59.4% of patients receiving placebo and in 14.7% of those receiving ampicillin (P<.0001). In those individuals undergoing primary cesarean section the incidence of infection with placebo was 65% and with ampicillin 6.3% (P<.0004). In patients undergoing repeat cesarean section the incidence was 53% in the placebo group and 22% in the treatment group (P>.05). There were no differences in the effectiveness of the drug whether given preoperatively or intraoperatively. Serious infections and wound infections were not encountered in patients receiving ampicillin.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 463-466 |
| Number of pages | 4 |
| Journal | Obstetrics and Gynecology |
| Volume | 61 |
| Issue number | 4 |
| State | Published - Jan 1 1983 |
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ASJC Scopus subject areas
- Obstetrics and Gynecology
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Single-Dose ampicillin for cesarean section prophylaxis. / Padilla, Santiago; Spence, Michael R.; Beauchamp, Pedro J.
In: Obstetrics and Gynecology, Vol. 61, No. 4, 01.01.1983, p. 463-466.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Single-Dose ampicillin for cesarean section prophylaxis
AU - Padilla, Santiago
AU - Spence, Michael R.
AU - Beauchamp, Pedro J.
PY - 1983/1/1
Y1 - 1983/1/1
N2 - A single 2-g dose of ampicillin or a placebo identical in appearance was administered intravenously in a randomized, prospective, double-blind manner to 71 patients undergoing cesarean section. The solutions were given either on call to the operating room or during the intraoperative period. Postoperative morbidity from infection occurred in 59.4% of patients receiving placebo and in 14.7% of those receiving ampicillin (P<.0001). In those individuals undergoing primary cesarean section the incidence of infection with placebo was 65% and with ampicillin 6.3% (P<.0004). In patients undergoing repeat cesarean section the incidence was 53% in the placebo group and 22% in the treatment group (P>.05). There were no differences in the effectiveness of the drug whether given preoperatively or intraoperatively. Serious infections and wound infections were not encountered in patients receiving ampicillin.
AB - A single 2-g dose of ampicillin or a placebo identical in appearance was administered intravenously in a randomized, prospective, double-blind manner to 71 patients undergoing cesarean section. The solutions were given either on call to the operating room or during the intraoperative period. Postoperative morbidity from infection occurred in 59.4% of patients receiving placebo and in 14.7% of those receiving ampicillin (P<.0001). In those individuals undergoing primary cesarean section the incidence of infection with placebo was 65% and with ampicillin 6.3% (P<.0004). In patients undergoing repeat cesarean section the incidence was 53% in the placebo group and 22% in the treatment group (P>.05). There were no differences in the effectiveness of the drug whether given preoperatively or intraoperatively. Serious infections and wound infections were not encountered in patients receiving ampicillin.
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UR - http://www.scopus.com/inward/citedby.url?scp=0020671748&partnerID=8YFLogxK
M3 - Article
C2 - 6828277
AN - SCOPUS:0020671748
VL - 61
SP - 463
EP - 466
JO - Obstetrics and Gynecology
JF - Obstetrics and Gynecology
SN - 0029-7844
IS - 4
ER -