@article{f2a95f4ca3db4e778ca9438c91faace2,
title = "Single-Cell Transcriptomes Reveal Diverse Regulatory Strategies for Olfactory Receptor Expression and Axon Targeting",
abstract = "In this study, Li et al. perform single-cell RNA sequencing of developing olfactory receptor neurons (ORNs) in Drosophila and reveal that ORNs utilize diverse transcriptional strategies to coordinate their olfactory receptor expression and axon targeting.",
keywords = "Drosophila, axon targeting, glomeruli, neuronal type, olfactory receptor, olfactory receptor neurons, olfactory system, single-cell RNA-seq",
author = "Hongjie Li and Tongchao Li and Felix Horns and Jiefu Li and Qijing Xie and Chuanyun Xu and Bing Wu and Kebschull, {Justus M.} and McLaughlin, {Colleen N.} and Kolluru, {Sai Saroja} and Jones, {Robert C.} and David Vacek and Anthony Xie and Luginbuhl, {David J.} and Quake, {Stephen R.} and Liqun Luo",
note = "Funding Information: We thank H. Bellen, L. Zipursky, I. Grunwald Kadow, J. Simpson, the Bloomington Drosophila Stock Center, and the Vienna Drosophila Resource Center for reagents; J. Lui and E. Richman for discussions; N. Neff, J. Okamoto, and Chan-Zuckerberg Biohub for assistance with sequencing; Y. Ge for assistance on fly work; and A. Shuster, J. Lui, and D. Pederick for comments on the manuscript. H.L. was a Stanford Neuroscience Institute interdisciplinary postdoctoral scholar. F.H. acknowledges support from the National Science Foundation Graduate Research Fellowship. J.L. acknowledges Genentech Foundation Predoctoral and Vanessa Kong Kerzner Graduate Fellowships. J.M.K. is a Fellow of the Jane Coffin Childs Memorial Fund. S.R.Q. is a Chan Zuckerberg investigator, and L.L. is a Howard Hughes Medical Institute (HHMI) investigator. This work was supported by National Institutes of Health grants 1K99AG062746-01 (to H.L.) and R01-DC005982 (to L.L.). Funding Information: We thank H. Bellen, L. Zipursky, I. Grunwald Kadow, J. Simpson, the Bloomington Drosophila Stock Center, and the Vienna Drosophila Resource Center for reagents; J. Lui and E. Richman for discussions; N. Neff, J. Okamoto, and Chan-Zuckerberg Biohub for assistance with sequencing; Y. Ge for assistance on fly work; and A. Shuster, J. Lui, and D. Pederick for comments on the manuscript. H.L. was a Stanford Neuroscience Institute interdisciplinary postdoctoral scholar. F.H. acknowledges support from the National Science Foundation Graduate Research Fellowship. J.L. acknowledges Genentech Foundation Predoctoral and Vanessa Kong Kerzner Graduate Fellowships. J.M.K. is a Fellow of the Jane Coffin Childs Memorial Fund. S.R.Q. is a Chan Zuckerberg investigator, and L.L. is a Howard Hughes Medical Institute (HHMI) investigator. This work was supported by National Institutes of Health grants 1K99AG062746-01 (to H.L.) and R01-DC005982 (to L.L.). H.L. and L.L. conceived this project. H.L. T.L. and L.L. designed experiments with support from F.H. and S.R.Q. H.L. and T.L collected samples and performed scRNA-seq. H.L. analyzed data with help from F.H. S.S.K. R.C.J. and J.M.K. T.L. performed DiI labeling experiments, and H.L. performed all other fly experiments with help from T.L. J.L. Q.X. C.X. B.W. C.N.M. D.V. A.X. and D.J.L. Q.X. performed qRT-PCR. H.L. and L.L. wrote the paper with input from T.L. F.H. and S.R.Q. The authors declare no competing interests. Publisher Copyright: {\textcopyright} 2020 Elsevier Ltd",
year = "2020",
month = apr,
day = "6",
doi = "10.1016/j.cub.2020.01.049",
language = "English (US)",
volume = "30",
pages = "1189--1198.e5",
journal = "Current Biology",
issn = "0960-9822",
publisher = "Cell Press",
number = "7",
}