Single-Cell Transcriptomes Reveal Diverse Regulatory Strategies for Olfactory Receptor Expression and Axon Targeting

Hongjie Li, Tongchao Li, Felix Horns, Jiefu Li, Qijing Xie, Chuanyun Xu, Bing Wu, Justus M. Kebschull, Colleen N. McLaughlin, Sai Saroja Kolluru, Robert C. Jones, David Vacek, Anthony Xie, David J. Luginbuhl, Stephen R. Quake, Liqun Luo

Research output: Contribution to journalArticlepeer-review

Abstract

In this study, Li et al. perform single-cell RNA sequencing of developing olfactory receptor neurons (ORNs) in Drosophila and reveal that ORNs utilize diverse transcriptional strategies to coordinate their olfactory receptor expression and axon targeting.

Original languageEnglish (US)
Pages (from-to)1189-1198.e5
JournalCurrent Biology
Volume30
Issue number7
DOIs
StatePublished - Apr 6 2020
Externally publishedYes

Keywords

  • Drosophila
  • axon targeting
  • glomeruli
  • neuronal type
  • olfactory receptor
  • olfactory receptor neurons
  • olfactory system
  • single-cell RNA-seq

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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