Single-agent adriamycin followed by combination hexamethylmelamine-cyclophosphamide for advanced ovarian carcinoma

J. Taylor Wharton, Jay Herson, Creighton L. Edwards, Augusta B. Griffith

Research output: Contribution to journalArticle

Abstract

Singleagent Adriamycin (ADM) induced a 21.8% response rate, surgically documented, in 32 previously untreated patients with advanced ovarian cancer. Patients with grade 3 carcinomas had a longer survival time than patients with grade 2 carcinomas (P = 0.07). A statistically significant interaction of grade and age was found (P = 0.01). Patients younger than 45 years had almost precisely the same risk of death per unit time, regardless of grade. Patients over age 45, with grade 3 tumors, had 3.6 times the risk of death per unit time, and those with grade 2 tumors had 45.5 times the risk as the patient under 45 years of age. Hexamethylmelamine-cyclophosphamide was active in four patients (17%) who failed to respond to ADM. ADM may exert significant but selective anti-tumor activity and deserves additional testing in drug combinations used in the treatment of ovarian cancer.

Original languageEnglish (US)
Pages (from-to)262-270
Number of pages9
JournalGynecologic oncology
Volume14
Issue number2
DOIs
StatePublished - Oct 1982
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology

Fingerprint Dive into the research topics of 'Single-agent adriamycin followed by combination hexamethylmelamine-cyclophosphamide for advanced ovarian carcinoma'. Together they form a unique fingerprint.

  • Cite this