Sincalide-stimulated cholescintigraphy: A multicenter investigation to determine optimal infusion methodology and gallbladder ejection fraction normal values

Harvey Ziessman, Mark Tulchinsky, William C. Lavely, John P. Gaughan, Thomas W. Allen, Ashley Maru, Henry P. Parkman, Alan H. Maurer

Research output: Contribution to journalArticle

Abstract

Sincalide-stimulated cholescintigraphy is performed to quantify gallbladder contraction and emptying. However, different infusion methods are used for this study. Our purpose was to determine the infusion method with the least variability (smallest coefficient of variation [CV]) for calculation of the gallbladder ejection fraction (GBEF) in healthy subjects and to establish normal values. Methods: Sixty healthy volunteers at 4 medical centers were injected intravenously with 99mTc-mebrofenin. After gallbladder visualization had been confirmed at 60 min, 0.02 mg of sincalide per kilogram was administered using 3 different infusion durations, 15, 30, and 60 min, each performed on separate days. The CV, mean, SD, first to 99th percentile, and fifth to 95th percentile were calculated. GBEF normal values were determined for the different infusion durations. Results: The CV was smallest for the 60-min infusion at 60 min (19%; 95% confidence interval [CI], 16%-23%), compared with the 30-min infusion at 30 min (35%; 95% CI, 29.2%-42.1%) and the 15-min infusion at 15 min (52%; 95% CI, 44%-63%). These were all significantly different (P

Original languageEnglish (US)
Pages (from-to)277-281
Number of pages5
JournalJournal of Nuclear Medicine
Volume51
Issue number2
DOIs
StatePublished - Feb 1 2010

Fingerprint

Sincalide
Gallbladder
Reference Values
Confidence Intervals
Healthy Volunteers
Gallbladder Emptying

Keywords

  • Cholescintigraphy
  • Gallbladder ejection fraction
  • Gastroenterology
  • Hepatology
  • Sincalide

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Sincalide-stimulated cholescintigraphy : A multicenter investigation to determine optimal infusion methodology and gallbladder ejection fraction normal values. / Ziessman, Harvey; Tulchinsky, Mark; Lavely, William C.; Gaughan, John P.; Allen, Thomas W.; Maru, Ashley; Parkman, Henry P.; Maurer, Alan H.

In: Journal of Nuclear Medicine, Vol. 51, No. 2, 01.02.2010, p. 277-281.

Research output: Contribution to journalArticle

Ziessman, Harvey ; Tulchinsky, Mark ; Lavely, William C. ; Gaughan, John P. ; Allen, Thomas W. ; Maru, Ashley ; Parkman, Henry P. ; Maurer, Alan H. / Sincalide-stimulated cholescintigraphy : A multicenter investigation to determine optimal infusion methodology and gallbladder ejection fraction normal values. In: Journal of Nuclear Medicine. 2010 ; Vol. 51, No. 2. pp. 277-281.
@article{ba2d33caa552493ba8c3fc8d65ffc152,
title = "Sincalide-stimulated cholescintigraphy: A multicenter investigation to determine optimal infusion methodology and gallbladder ejection fraction normal values",
abstract = "Sincalide-stimulated cholescintigraphy is performed to quantify gallbladder contraction and emptying. However, different infusion methods are used for this study. Our purpose was to determine the infusion method with the least variability (smallest coefficient of variation [CV]) for calculation of the gallbladder ejection fraction (GBEF) in healthy subjects and to establish normal values. Methods: Sixty healthy volunteers at 4 medical centers were injected intravenously with 99mTc-mebrofenin. After gallbladder visualization had been confirmed at 60 min, 0.02 mg of sincalide per kilogram was administered using 3 different infusion durations, 15, 30, and 60 min, each performed on separate days. The CV, mean, SD, first to 99th percentile, and fifth to 95th percentile were calculated. GBEF normal values were determined for the different infusion durations. Results: The CV was smallest for the 60-min infusion at 60 min (19{\%}; 95{\%} confidence interval [CI], 16{\%}-23{\%}), compared with the 30-min infusion at 30 min (35{\%}; 95{\%} CI, 29.2{\%}-42.1{\%}) and the 15-min infusion at 15 min (52{\%}; 95{\%} CI, 44{\%}-63{\%}). These were all significantly different (P",
keywords = "Cholescintigraphy, Gallbladder ejection fraction, Gastroenterology, Hepatology, Sincalide",
author = "Harvey Ziessman and Mark Tulchinsky and Lavely, {William C.} and Gaughan, {John P.} and Allen, {Thomas W.} and Ashley Maru and Parkman, {Henry P.} and Maurer, {Alan H.}",
year = "2010",
month = "2",
day = "1",
doi = "10.2967/jnumed.109.069393",
language = "English (US)",
volume = "51",
pages = "277--281",
journal = "Journal of Nuclear Medicine",
issn = "0161-5505",
publisher = "Society of Nuclear Medicine Inc.",
number = "2",

}

TY - JOUR

T1 - Sincalide-stimulated cholescintigraphy

T2 - A multicenter investigation to determine optimal infusion methodology and gallbladder ejection fraction normal values

AU - Ziessman, Harvey

AU - Tulchinsky, Mark

AU - Lavely, William C.

AU - Gaughan, John P.

AU - Allen, Thomas W.

AU - Maru, Ashley

AU - Parkman, Henry P.

AU - Maurer, Alan H.

PY - 2010/2/1

Y1 - 2010/2/1

N2 - Sincalide-stimulated cholescintigraphy is performed to quantify gallbladder contraction and emptying. However, different infusion methods are used for this study. Our purpose was to determine the infusion method with the least variability (smallest coefficient of variation [CV]) for calculation of the gallbladder ejection fraction (GBEF) in healthy subjects and to establish normal values. Methods: Sixty healthy volunteers at 4 medical centers were injected intravenously with 99mTc-mebrofenin. After gallbladder visualization had been confirmed at 60 min, 0.02 mg of sincalide per kilogram was administered using 3 different infusion durations, 15, 30, and 60 min, each performed on separate days. The CV, mean, SD, first to 99th percentile, and fifth to 95th percentile were calculated. GBEF normal values were determined for the different infusion durations. Results: The CV was smallest for the 60-min infusion at 60 min (19%; 95% confidence interval [CI], 16%-23%), compared with the 30-min infusion at 30 min (35%; 95% CI, 29.2%-42.1%) and the 15-min infusion at 15 min (52%; 95% CI, 44%-63%). These were all significantly different (P

AB - Sincalide-stimulated cholescintigraphy is performed to quantify gallbladder contraction and emptying. However, different infusion methods are used for this study. Our purpose was to determine the infusion method with the least variability (smallest coefficient of variation [CV]) for calculation of the gallbladder ejection fraction (GBEF) in healthy subjects and to establish normal values. Methods: Sixty healthy volunteers at 4 medical centers were injected intravenously with 99mTc-mebrofenin. After gallbladder visualization had been confirmed at 60 min, 0.02 mg of sincalide per kilogram was administered using 3 different infusion durations, 15, 30, and 60 min, each performed on separate days. The CV, mean, SD, first to 99th percentile, and fifth to 95th percentile were calculated. GBEF normal values were determined for the different infusion durations. Results: The CV was smallest for the 60-min infusion at 60 min (19%; 95% confidence interval [CI], 16%-23%), compared with the 30-min infusion at 30 min (35%; 95% CI, 29.2%-42.1%) and the 15-min infusion at 15 min (52%; 95% CI, 44%-63%). These were all significantly different (P

KW - Cholescintigraphy

KW - Gallbladder ejection fraction

KW - Gastroenterology

KW - Hepatology

KW - Sincalide

UR - http://www.scopus.com/inward/record.url?scp=75749132036&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=75749132036&partnerID=8YFLogxK

U2 - 10.2967/jnumed.109.069393

DO - 10.2967/jnumed.109.069393

M3 - Article

C2 - 20080900

AN - SCOPUS:75749132036

VL - 51

SP - 277

EP - 281

JO - Journal of Nuclear Medicine

JF - Journal of Nuclear Medicine

SN - 0161-5505

IS - 2

ER -