Simultaneously Examination of P53 and C-erbB-2 in Gastroscopic Stomach Tissues

Xiao Feng Jia, Da Ren Shi, Zhu Qin Le, Hong Feng Lu, Yue Zhen Fan

Research output: Contribution to journalArticle

Abstract

Purpose: To investigate the expression of P53 and C-erbB-2 in gastroscopic Stomach Tissues for redounding to early clinical diagnosis and screening high risk population of gastric carcinomas. Methods: We examined simultaneously with immunohistochemical staining ABC in 15 normal mucosa, 16 mild, 15 moderate, 13 severe intestinal metaplasia tissues and 14 gastric carcinoma tissues. Results: Immunohistochemical positive specimens of P53 and C-erbB-2 found in gastric carcinoma tissues were 8/14(57.1%) and 7/14(50%) respectively. The sensitivity and specificity of immunohistochemical positive rate with double expression of C-erbB-2 and P53 were 28.6% and 100%, while that of Complex expression (C-erbB-2 and/or P53) were 84.6% and 88.1% respectively. Conclusions: C-erbB-2 can be used as a label in clinical diagnosis for gastric carcinoma because of the high specificity. Double expressin of C-erbB-2 and P53 can be used in early clinical diagnosis. Complex expression can be used to screen high risk population of gastric carcinomas.

Original languageEnglish (US)
Pages (from-to)579-581
Number of pages3
JournalFudan University Journal of Medical Sciences
Volume30
Issue number6
StatePublished - Nov 2003
Externally publishedYes

Keywords

  • C-erbB -2
  • Gastric carcinoma
  • Immunohistochemical staining
  • Intestinal metaplasia
  • P53
  • Simultaneous examination

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Jia, X. F., Shi, D. R., Le, Z. Q., Lu, H. F., & Fan, Y. Z. (2003). Simultaneously Examination of P53 and C-erbB-2 in Gastroscopic Stomach Tissues. Fudan University Journal of Medical Sciences, 30(6), 579-581.