Simultaneous water and lipid suppression for in vivo brain spectroscopy in humans

Mari A. Smith, Joseph Gillen, Michael T. McMahon, Peter B. Barker, Xavier Golay

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


A method to achieve simultaneous water and lipid suppression is described. The key feature of the new dual suppression technique is the use of the well-known hyperbolic secant (HS) waveform as a 90° saturation pulse. Two HS pulses with opposite frequency offsets are employed either sequentially or simultaneously to saturate resonance frequencies corresponding to water and lipid, while leaving the target spins untouched. The excitation bandwidth is controlled by the frequency sweep and offset of each pulse, while varying the pulse length controls the transition bandwidth. An example of the use of the dual saturation method in in vivo magnetic resonance spectroscopic imaging of the human brain is presented.

Original languageEnglish (US)
Pages (from-to)691-696
Number of pages6
JournalMagnetic resonance in medicine
Issue number3
StatePublished - Sep 2005


  • Brain
  • Lipid suppression
  • MRS
  • MRSI
  • Water suppression

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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