Simultaneous vitamin A administration at routine immunization contact enhances antibody response to diphtheria vaccine in infants younger than six months

M. M. Rahman, D. Mahalanabis, S. Hossain, M. A. Wahed, J. O. Alvarez, G. R. Siber, Claudette Thompson, M. Santosham, G. J. Fuchs

Research output: Contribution to journalArticlepeer-review

Abstract

A randomized, double-blind, placebo-controlled trial was conducted to evaluate the effect of simultaneous vitamin A supplementation and diphtheria, pertussis and tetanus (DPT) vaccination on the antibody levels. Infants aged 6-17 wk (n = 56) were randomly given 15 mg oral vitamin A or placebo at the time of their DPT immunization. Three such doses were given at monthly intervals. Immunoglobulin (Ig) G antibodies to diphtheria, pertussis and tetanus were assayed on enrollment and 1 mo after the third dose. Baseline antibody concentrations to diphtheria, pertussis and tetanus did not differ between the vitamin A-supplemented and placebo-treated groups. The postdose antibody to diphtheria level was significantly greater in the vitamin A than in the placebo-treated group. The geometric mean ± SEM antibody levels (mg/L) were 22.9 ± 1.2 and 11.0 ± 1.3 in the vitamin A and placebo groups, respectively (P = 0.029). The postsupplementation concentrations of antibodies to pertussis and tetanus did not differ between the two groups. These results suggest that antibody response to diphtheria vaccination was potentiated by simultaneous vitamin A administration and DPT immunization.

Original languageEnglish (US)
Pages (from-to)2192-2195
Number of pages4
JournalJournal of Nutrition
Volume129
Issue number12
DOIs
StatePublished - 1999

Keywords

  • Antibody
  • Diphtheria
  • Immunization
  • Infants
  • Pertussis
  • Tetanus
  • Vitamin A

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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