Simultaneous thoracic and abdominal transplantation: Can we justify two organs for one recipient?

J. H. Wolf, M. E. Sulewski, J. R. Cassuto, M. H. Levine, A. Naji, K. M. Olthoff, A. Shaked, P. L. Abt

Research output: Contribution to journalArticlepeer-review

Abstract

Simultaneous thoracic and abdominal (STA) transplantation is controversial because two organs are allocated to a single individual. We studied wait-list urgency, and whether transplantation led to successful outcomes. Candidates and recipients for heart-kidney (SHK), heart-liver (SHLi), lung-liver (SLuLi) and lung-kidney (SLuK) were identified through the United Network for Organ Sharing (UNOS) and outcomes were compared to single-organ transplantation. Since 1987, there were 1801 STA candidates and 836 recipients. Wait-list survival at 1- and 3 years for SHK (67.4%, 40.8%; N = 1420), SHLi (65.7%, 43.6%; N = 218) and SLuLi (65.7%, 41.0%; N = 122), was lower than controls (p < 0.001), whereas for SLuK (65.0%, 51.6%; N = 41) it was comparable (p = 0.34). All STA groups demonstrated similar 1- and 5 years posttransplant survival to thoracic controls. Compared to abdominal controls, 1- and 5 years posttransplant survival in SHK (85.3%, 74.0%; N = 684), SLuLi (75.5%, 59.0%; N = 42) and SLuK (66.7%, 55.6%; N = 18) was decreased (p < 0.01), but SHLi (85.9%, 74.3%; N = 92) was comparable (p = 0.81). In summary, STA candidates had greater risk of wait-list mortality compared to single-organ candidates. STA outcomes were similar to thoracic transplantation; however, outcomes were similar to abdominal transplantation for SHLi only. Although select patients benefit from STA, risk-exposure variables for decreased survival should be identified, aiming to eliminate futile transplantation.

Original languageEnglish (US)
Pages (from-to)1806-1816
Number of pages11
JournalAmerican Journal of Transplantation
Volume13
Issue number7
DOIs
StatePublished - Jul 2013
Externally publishedYes

Keywords

  • Combined transplants
  • heart transplantation
  • kidney transplantation
  • liver transplantation
  • lung transplantation

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation
  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'Simultaneous thoracic and abdominal transplantation: Can we justify two organs for one recipient?'. Together they form a unique fingerprint.

Cite this