Simultaneous technetium-99m/thallium-201 SPECT imaging with model-based compensation for cross-contaminating effects

Dan J. Kadrmas, Eric Frey, Benjamin Tsui

Research output: Contribution to journalArticle

Abstract

Simultaneous acquisition of dual-isotope SPECT data offers a number of advantages over separately acquired data; however, simultaneous acquisition can result in cross-contamination between isotopes. In this work we propose and evaluate two frameworks for iterative model-based compensation of cross- contamination in dual-isotope SPECT. The methods were applied to cardiac imaging with technetium-99m-sestamibi and thallium-201, and they were compared with a subtraction-based compensation method using a cross-talk estimate obtained from an auxiliary energy window. Monte Carlo simulations were performed to carefully study aspects of bias and noise for the methods, and a torso phantom with cardiac insert was used to evaluate the performance of the methods for experimentally acquired data. The cross-talk compensation methods substantially improved lesion contrast and significantly reduced quantitative errors for simultaneously acquired data. Thallium image normalized mean square error (NMSE) was reduced from 0.522 without cross- talk compensation to as low as 0.052 with model-based cross-talk compensation. This is compared with a NMSE of 0.091 for the subtraction- based compensation method. The application of a preliminary model for cross- talk arising from lead fluorescence x-rays and collimator scatter gave promising results, and the future development of a more accurate model for collimator interactions would probably benefit simultaneous Tc/Tl imaging. Model-based compensation methods provide feasible cross-talk compensation in clinically acceptable times, and they may ultimately make simultaneous dual- isotope protocols an effective alternative for many imaging procedures.

Original languageEnglish (US)
Pages (from-to)1843-1860
Number of pages18
JournalPhysics in Medicine and Biology
Volume44
Issue number7
DOIs
StatePublished - Jul 1999

Fingerprint

Technetium
technetium
Thallium
thallium
Single-Photon Emission-Computed Tomography
Imaging techniques
Isotopes
isotopes
collimators
Crosstalk
crosstalk
subtraction
Mean square error
acquisition
contamination
Contamination
torso
Technetium Tc 99m Sestamibi
Torso
x ray fluorescence

ASJC Scopus subject areas

  • Biomedical Engineering
  • Physics and Astronomy (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

@article{f94f1d04fa3049ab9699f8c7c983c79f,
title = "Simultaneous technetium-99m/thallium-201 SPECT imaging with model-based compensation for cross-contaminating effects",
abstract = "Simultaneous acquisition of dual-isotope SPECT data offers a number of advantages over separately acquired data; however, simultaneous acquisition can result in cross-contamination between isotopes. In this work we propose and evaluate two frameworks for iterative model-based compensation of cross- contamination in dual-isotope SPECT. The methods were applied to cardiac imaging with technetium-99m-sestamibi and thallium-201, and they were compared with a subtraction-based compensation method using a cross-talk estimate obtained from an auxiliary energy window. Monte Carlo simulations were performed to carefully study aspects of bias and noise for the methods, and a torso phantom with cardiac insert was used to evaluate the performance of the methods for experimentally acquired data. The cross-talk compensation methods substantially improved lesion contrast and significantly reduced quantitative errors for simultaneously acquired data. Thallium image normalized mean square error (NMSE) was reduced from 0.522 without cross- talk compensation to as low as 0.052 with model-based cross-talk compensation. This is compared with a NMSE of 0.091 for the subtraction- based compensation method. The application of a preliminary model for cross- talk arising from lead fluorescence x-rays and collimator scatter gave promising results, and the future development of a more accurate model for collimator interactions would probably benefit simultaneous Tc/Tl imaging. Model-based compensation methods provide feasible cross-talk compensation in clinically acceptable times, and they may ultimately make simultaneous dual- isotope protocols an effective alternative for many imaging procedures.",
author = "Kadrmas, {Dan J.} and Eric Frey and Benjamin Tsui",
year = "1999",
month = "7",
doi = "10.1088/0031-9155/44/7/319",
language = "English (US)",
volume = "44",
pages = "1843--1860",
journal = "Physics in Medicine and Biology",
issn = "0031-9155",
publisher = "IOP Publishing Ltd.",
number = "7",

}

TY - JOUR

T1 - Simultaneous technetium-99m/thallium-201 SPECT imaging with model-based compensation for cross-contaminating effects

AU - Kadrmas, Dan J.

AU - Frey, Eric

AU - Tsui, Benjamin

PY - 1999/7

Y1 - 1999/7

N2 - Simultaneous acquisition of dual-isotope SPECT data offers a number of advantages over separately acquired data; however, simultaneous acquisition can result in cross-contamination between isotopes. In this work we propose and evaluate two frameworks for iterative model-based compensation of cross- contamination in dual-isotope SPECT. The methods were applied to cardiac imaging with technetium-99m-sestamibi and thallium-201, and they were compared with a subtraction-based compensation method using a cross-talk estimate obtained from an auxiliary energy window. Monte Carlo simulations were performed to carefully study aspects of bias and noise for the methods, and a torso phantom with cardiac insert was used to evaluate the performance of the methods for experimentally acquired data. The cross-talk compensation methods substantially improved lesion contrast and significantly reduced quantitative errors for simultaneously acquired data. Thallium image normalized mean square error (NMSE) was reduced from 0.522 without cross- talk compensation to as low as 0.052 with model-based cross-talk compensation. This is compared with a NMSE of 0.091 for the subtraction- based compensation method. The application of a preliminary model for cross- talk arising from lead fluorescence x-rays and collimator scatter gave promising results, and the future development of a more accurate model for collimator interactions would probably benefit simultaneous Tc/Tl imaging. Model-based compensation methods provide feasible cross-talk compensation in clinically acceptable times, and they may ultimately make simultaneous dual- isotope protocols an effective alternative for many imaging procedures.

AB - Simultaneous acquisition of dual-isotope SPECT data offers a number of advantages over separately acquired data; however, simultaneous acquisition can result in cross-contamination between isotopes. In this work we propose and evaluate two frameworks for iterative model-based compensation of cross- contamination in dual-isotope SPECT. The methods were applied to cardiac imaging with technetium-99m-sestamibi and thallium-201, and they were compared with a subtraction-based compensation method using a cross-talk estimate obtained from an auxiliary energy window. Monte Carlo simulations were performed to carefully study aspects of bias and noise for the methods, and a torso phantom with cardiac insert was used to evaluate the performance of the methods for experimentally acquired data. The cross-talk compensation methods substantially improved lesion contrast and significantly reduced quantitative errors for simultaneously acquired data. Thallium image normalized mean square error (NMSE) was reduced from 0.522 without cross- talk compensation to as low as 0.052 with model-based cross-talk compensation. This is compared with a NMSE of 0.091 for the subtraction- based compensation method. The application of a preliminary model for cross- talk arising from lead fluorescence x-rays and collimator scatter gave promising results, and the future development of a more accurate model for collimator interactions would probably benefit simultaneous Tc/Tl imaging. Model-based compensation methods provide feasible cross-talk compensation in clinically acceptable times, and they may ultimately make simultaneous dual- isotope protocols an effective alternative for many imaging procedures.

UR - http://www.scopus.com/inward/record.url?scp=0032783218&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032783218&partnerID=8YFLogxK

U2 - 10.1088/0031-9155/44/7/319

DO - 10.1088/0031-9155/44/7/319

M3 - Article

C2 - 10442716

AN - SCOPUS:0032783218

VL - 44

SP - 1843

EP - 1860

JO - Physics in Medicine and Biology

JF - Physics in Medicine and Biology

SN - 0031-9155

IS - 7

ER -