Simultaneous segmentation of retinal surfaces and microcystic macular edema in SDOCT volumes

Bhavna J. Antony, Andrew Lang, Emily K. Swingle, Omar Al-Louzi, Aaron Carass, Sharon Solomon, Peter Calabresi, Shiv Saidha, Jerry Ladd Prince

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Optical coherence tomography (OCT) is a noninvasive imaging modality that has begun to find widespread use in retinal imaging for the detection of a variety of ocular diseases. In addition to structural changes in the form of altered retinal layer thicknesses, pathological conditions may also cause the formation of edema within the retina. In multiple sclerosis, for instance, the nerve fiber and ganglion cell layers are known to thin. Additionally, the formation of pseudocysts called microcystic macular edema (MME) have also been observed in the eyes of about 5% of MS patients, and its presence has been shown to be correlated with disease severity. Previously, we proposed separate algorithms for the segmentation of retinal layers and MME, but since MME mainly occurs within specific regions of the retina, a simultaneous approach is advantageous. In this work, we propose an automated globally optimal graph-theoretic approach that simultaneously segments the retinal layers and the MME in volumetric OCT scans. SD-OCT scans from one eye of 12 MS patients with known MME and 8 healthy controls were acquired and the pseudocysts manually traced. The overall precision and recall of the pseudocyst detection was found to be 86.0% and 79.5%, respectively.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2016: Image Processing
PublisherSPIE
Volume9784
ISBN (Electronic)9781510600195
DOIs
StatePublished - 2016
EventMedical Imaging 2016: Image Processing - San Diego, United States
Duration: Mar 1 2016Mar 3 2016

Other

OtherMedical Imaging 2016: Image Processing
CountryUnited States
CitySan Diego
Period3/1/163/3/16

Fingerprint

edema
Macular Edema
Optical tomography
Optical Coherence Tomography
Imaging techniques
retina
tomography
Retina
Cells
Eye Diseases
nerve fibers
Nerve Fibers
Fibers
Ganglia
Multiple Sclerosis
Edema
causes

Keywords

  • Graph-cuts
  • Graph-theoretic approach
  • Microcysts
  • Multiple surface segmentation
  • Optical coherence to- mography
  • Retina

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Antony, B. J., Lang, A., Swingle, E. K., Al-Louzi, O., Carass, A., Solomon, S., ... Prince, J. L. (2016). Simultaneous segmentation of retinal surfaces and microcystic macular edema in SDOCT volumes. In Medical Imaging 2016: Image Processing (Vol. 9784). [97841C] SPIE. https://doi.org/10.1117/12.2214676

Simultaneous segmentation of retinal surfaces and microcystic macular edema in SDOCT volumes. / Antony, Bhavna J.; Lang, Andrew; Swingle, Emily K.; Al-Louzi, Omar; Carass, Aaron; Solomon, Sharon; Calabresi, Peter; Saidha, Shiv; Prince, Jerry Ladd.

Medical Imaging 2016: Image Processing. Vol. 9784 SPIE, 2016. 97841C.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Antony, BJ, Lang, A, Swingle, EK, Al-Louzi, O, Carass, A, Solomon, S, Calabresi, P, Saidha, S & Prince, JL 2016, Simultaneous segmentation of retinal surfaces and microcystic macular edema in SDOCT volumes. in Medical Imaging 2016: Image Processing. vol. 9784, 97841C, SPIE, Medical Imaging 2016: Image Processing, San Diego, United States, 3/1/16. https://doi.org/10.1117/12.2214676
Antony BJ, Lang A, Swingle EK, Al-Louzi O, Carass A, Solomon S et al. Simultaneous segmentation of retinal surfaces and microcystic macular edema in SDOCT volumes. In Medical Imaging 2016: Image Processing. Vol. 9784. SPIE. 2016. 97841C https://doi.org/10.1117/12.2214676
Antony, Bhavna J. ; Lang, Andrew ; Swingle, Emily K. ; Al-Louzi, Omar ; Carass, Aaron ; Solomon, Sharon ; Calabresi, Peter ; Saidha, Shiv ; Prince, Jerry Ladd. / Simultaneous segmentation of retinal surfaces and microcystic macular edema in SDOCT volumes. Medical Imaging 2016: Image Processing. Vol. 9784 SPIE, 2016.
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