Simultaneous resections of colorectal cancer and synchronous liver metastases: A multi-institutional analysis

Srinevas K. Reddy, Timothy M. Pawlik, Daria Zorzi, Ana L. Gleisner, Dario Ribero, Lia Assumpcao, Andrew S. Barbas, Eddie K. Abdalla, Michael A. Choti, Jean Nicolas Vauthey, Kirk A. Ludwig, Christopher R. Mantyh, Michael A. Morse, Bryan M. Clary

Research output: Contribution to journalArticle

Abstract

Background: The safety of simultaneous resections of colorectal cancer and synchronous liver metastases (SCRLM) is not established. This multi-institutional retrospective study compared postoperative outcomes after simultaneous and staged colorectal and hepatic resections. Methods: Clinicopathologic data, treatments, and postoperative outcomes from patients who underwent simultaneous or staged colorectal and hepatic resections at three hepatobiliary centers from 1985-2006 were reviewed. Results: 610 patients underwent simultaneous (n = 135) or staged (n = 475) resections of colorectal cancer and SCRLM. Seventy staged patients underwent colorectal and hepatic resections at the same institution. Simultaneous patients had fewer (median 1 versus 2) and smaller (median 2.5 versus 3.5 cm) metastases and less often underwent major (≥ three segments) hepatectomy (26.7% versus 61.3%, p <0.05). Combined hospital stay was lower after simultaneous resections (median 8.5 versus 14 days, p <0.0001). Mortality (1.0% versus 0.5%) and severe morbidity (14.1% versus 12.5%) were similar after simultaneous colorectal resection and minor hepatectomy compared with isolated minor hepatectomy (both p > 0.05). For major hepatectomy, simultaneous colorectal resection increased mortality (8.3% versus 1.4%, p <0.05) and severe morbidity (36.1% versus 15.1%, p <0.05). Combined severe morbidity after staged resections was lower compared to simultaneous resections (36.1% versus 17.6%, p = 0.05) for major hepatectomy but similar for minor hepatectomy (14.1% versus 10.5%, p > 0.05). Major hepatectomy independently predicted severe morbidity after simultaneous resections [hazard ratio (HR) = 3.4, p = 0.008]. Conclusions: Simultaneous colorectal and minor hepatic resections are safe and should be performed for most patients with SCRLM. Due to increased risk of severe morbidity, caution should be exercised before performing simultaneous colorectal and major hepatic resections.

Original languageEnglish (US)
Pages (from-to)3481-3491
Number of pages11
JournalAnnals of Surgical Oncology
Volume14
Issue number12
DOIs
StatePublished - Dec 2007

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Liver Neoplasms
Colorectal Neoplasms
Neoplasm Metastasis
Liver
Hepatectomy
Morbidity
Retrospective Studies
Safety
Mortality

Keywords

  • Chemotherapy
  • Colorectal cancer
  • Hepatectomy
  • Hepatic metastases
  • Resection
  • Simultaneous

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Reddy, S. K., Pawlik, T. M., Zorzi, D., Gleisner, A. L., Ribero, D., Assumpcao, L., ... Clary, B. M. (2007). Simultaneous resections of colorectal cancer and synchronous liver metastases: A multi-institutional analysis. Annals of Surgical Oncology, 14(12), 3481-3491. https://doi.org/10.1245/s10434-007-9522-5

Simultaneous resections of colorectal cancer and synchronous liver metastases : A multi-institutional analysis. / Reddy, Srinevas K.; Pawlik, Timothy M.; Zorzi, Daria; Gleisner, Ana L.; Ribero, Dario; Assumpcao, Lia; Barbas, Andrew S.; Abdalla, Eddie K.; Choti, Michael A.; Vauthey, Jean Nicolas; Ludwig, Kirk A.; Mantyh, Christopher R.; Morse, Michael A.; Clary, Bryan M.

In: Annals of Surgical Oncology, Vol. 14, No. 12, 12.2007, p. 3481-3491.

Research output: Contribution to journalArticle

Reddy, SK, Pawlik, TM, Zorzi, D, Gleisner, AL, Ribero, D, Assumpcao, L, Barbas, AS, Abdalla, EK, Choti, MA, Vauthey, JN, Ludwig, KA, Mantyh, CR, Morse, MA & Clary, BM 2007, 'Simultaneous resections of colorectal cancer and synchronous liver metastases: A multi-institutional analysis', Annals of Surgical Oncology, vol. 14, no. 12, pp. 3481-3491. https://doi.org/10.1245/s10434-007-9522-5
Reddy, Srinevas K. ; Pawlik, Timothy M. ; Zorzi, Daria ; Gleisner, Ana L. ; Ribero, Dario ; Assumpcao, Lia ; Barbas, Andrew S. ; Abdalla, Eddie K. ; Choti, Michael A. ; Vauthey, Jean Nicolas ; Ludwig, Kirk A. ; Mantyh, Christopher R. ; Morse, Michael A. ; Clary, Bryan M. / Simultaneous resections of colorectal cancer and synchronous liver metastases : A multi-institutional analysis. In: Annals of Surgical Oncology. 2007 ; Vol. 14, No. 12. pp. 3481-3491.
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abstract = "Background: The safety of simultaneous resections of colorectal cancer and synchronous liver metastases (SCRLM) is not established. This multi-institutional retrospective study compared postoperative outcomes after simultaneous and staged colorectal and hepatic resections. Methods: Clinicopathologic data, treatments, and postoperative outcomes from patients who underwent simultaneous or staged colorectal and hepatic resections at three hepatobiliary centers from 1985-2006 were reviewed. Results: 610 patients underwent simultaneous (n = 135) or staged (n = 475) resections of colorectal cancer and SCRLM. Seventy staged patients underwent colorectal and hepatic resections at the same institution. Simultaneous patients had fewer (median 1 versus 2) and smaller (median 2.5 versus 3.5 cm) metastases and less often underwent major (≥ three segments) hepatectomy (26.7{\%} versus 61.3{\%}, p <0.05). Combined hospital stay was lower after simultaneous resections (median 8.5 versus 14 days, p <0.0001). Mortality (1.0{\%} versus 0.5{\%}) and severe morbidity (14.1{\%} versus 12.5{\%}) were similar after simultaneous colorectal resection and minor hepatectomy compared with isolated minor hepatectomy (both p > 0.05). For major hepatectomy, simultaneous colorectal resection increased mortality (8.3{\%} versus 1.4{\%}, p <0.05) and severe morbidity (36.1{\%} versus 15.1{\%}, p <0.05). Combined severe morbidity after staged resections was lower compared to simultaneous resections (36.1{\%} versus 17.6{\%}, p = 0.05) for major hepatectomy but similar for minor hepatectomy (14.1{\%} versus 10.5{\%}, p > 0.05). Major hepatectomy independently predicted severe morbidity after simultaneous resections [hazard ratio (HR) = 3.4, p = 0.008]. Conclusions: Simultaneous colorectal and minor hepatic resections are safe and should be performed for most patients with SCRLM. Due to increased risk of severe morbidity, caution should be exercised before performing simultaneous colorectal and major hepatic resections.",
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T1 - Simultaneous resections of colorectal cancer and synchronous liver metastases

T2 - A multi-institutional analysis

AU - Reddy, Srinevas K.

AU - Pawlik, Timothy M.

AU - Zorzi, Daria

AU - Gleisner, Ana L.

AU - Ribero, Dario

AU - Assumpcao, Lia

AU - Barbas, Andrew S.

AU - Abdalla, Eddie K.

AU - Choti, Michael A.

AU - Vauthey, Jean Nicolas

AU - Ludwig, Kirk A.

AU - Mantyh, Christopher R.

AU - Morse, Michael A.

AU - Clary, Bryan M.

PY - 2007/12

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N2 - Background: The safety of simultaneous resections of colorectal cancer and synchronous liver metastases (SCRLM) is not established. This multi-institutional retrospective study compared postoperative outcomes after simultaneous and staged colorectal and hepatic resections. Methods: Clinicopathologic data, treatments, and postoperative outcomes from patients who underwent simultaneous or staged colorectal and hepatic resections at three hepatobiliary centers from 1985-2006 were reviewed. Results: 610 patients underwent simultaneous (n = 135) or staged (n = 475) resections of colorectal cancer and SCRLM. Seventy staged patients underwent colorectal and hepatic resections at the same institution. Simultaneous patients had fewer (median 1 versus 2) and smaller (median 2.5 versus 3.5 cm) metastases and less often underwent major (≥ three segments) hepatectomy (26.7% versus 61.3%, p <0.05). Combined hospital stay was lower after simultaneous resections (median 8.5 versus 14 days, p <0.0001). Mortality (1.0% versus 0.5%) and severe morbidity (14.1% versus 12.5%) were similar after simultaneous colorectal resection and minor hepatectomy compared with isolated minor hepatectomy (both p > 0.05). For major hepatectomy, simultaneous colorectal resection increased mortality (8.3% versus 1.4%, p <0.05) and severe morbidity (36.1% versus 15.1%, p <0.05). Combined severe morbidity after staged resections was lower compared to simultaneous resections (36.1% versus 17.6%, p = 0.05) for major hepatectomy but similar for minor hepatectomy (14.1% versus 10.5%, p > 0.05). Major hepatectomy independently predicted severe morbidity after simultaneous resections [hazard ratio (HR) = 3.4, p = 0.008]. Conclusions: Simultaneous colorectal and minor hepatic resections are safe and should be performed for most patients with SCRLM. Due to increased risk of severe morbidity, caution should be exercised before performing simultaneous colorectal and major hepatic resections.

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KW - Colorectal cancer

KW - Hepatectomy

KW - Hepatic metastases

KW - Resection

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