Simultaneous radiofrequency (RF) heating and magnetic resonance (MR) thermal mapping using an intravascular MR imaging/RF heating system

Bensheng Qiu, Abdel Monem El-Sharkawy, Vaishali Paliwal, Parag Perry Karmarkar, Fabao Gao, Ergin Atalar, Xiaoming Yang

Research output: Contribution to journalArticle

Abstract

Previous studies have confirmed the possibility of using an intravascular MR imaging guidewire (MRIG) as a heating source to enhance vascular gene transfection/expression. This motivated us to develop a new intravascular system that can perform MR imaging, radiofrequncy (RF) heating, and MR temperature monitoring simultaneously in an MR scanner. To validate this concept, a series of mathematical simulations of RF power loss along a 0.032-inch MRIG and RF energy spatial distribution were performed to determine the optimum RF heating frequency. Then, an RF generator/amplifier and a filter box were built. The possibility for simultaneous RF heating and MR thermal mapping of the system was confirmed in vitro using a phantom, and the obtained thermal mapping profile was compared with the simulated RF power distribution. Subsequently, the feasibility of simultaneous RF heating and temperature monitoring was successfully validated in vivo in the aorta of living rabbits. This MR imaging/RF heating system offers a potential tool for intravascular MR-mediated, RF-enhanced vascular gene therapy.

Original languageEnglish (US)
Pages (from-to)226-230
Number of pages5
JournalMagnetic Resonance in Medicine
Volume54
Issue number1
DOIs
StatePublished - Jul 2005

Fingerprint

Heating
Magnetic Resonance Spectroscopy
Hot Temperature
Magnetic Resonance Imaging
Blood Vessels
Temperature
Genetic Therapy
Transfection
Aorta
Rabbits
Gene Expression

Keywords

  • Gene therapy
  • Intravascular MRI
  • MR imaging guide-wire
  • MR thermal mapping
  • Radiofrequency

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Simultaneous radiofrequency (RF) heating and magnetic resonance (MR) thermal mapping using an intravascular MR imaging/RF heating system. / Qiu, Bensheng; El-Sharkawy, Abdel Monem; Paliwal, Vaishali; Karmarkar, Parag Perry; Gao, Fabao; Atalar, Ergin; Yang, Xiaoming.

In: Magnetic Resonance in Medicine, Vol. 54, No. 1, 07.2005, p. 226-230.

Research output: Contribution to journalArticle

Qiu, Bensheng ; El-Sharkawy, Abdel Monem ; Paliwal, Vaishali ; Karmarkar, Parag Perry ; Gao, Fabao ; Atalar, Ergin ; Yang, Xiaoming. / Simultaneous radiofrequency (RF) heating and magnetic resonance (MR) thermal mapping using an intravascular MR imaging/RF heating system. In: Magnetic Resonance in Medicine. 2005 ; Vol. 54, No. 1. pp. 226-230.
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