Simultaneous radiofrequency (RF) heating and magnetic resonance (MR) thermal mapping using an intravascular MR imaging/RF heating system

Bensheng Qiu, Abdel Monem El-Sharkawy, Vaishali Paliwal, Parag Karmarkar, Fabao Gao, Ergin Atalar, Xiaoming Yang

Research output: Contribution to journalArticle

Abstract

Previous studies have confirmed the possibility of using an intravascular MR imaging guidewire (MRIG) as a heating source to enhance vascular gene transfection/expression. This motivated us to develop a new intravascular system that can perform MR imaging, radiofrequncy (RF) heating, and MR temperature monitoring simultaneously in an MR scanner. To validate this concept, a series of mathematical simulations of RF power loss along a 0.032-inch MRIG and RF energy spatial distribution were performed to determine the optimum RF heating frequency. Then, an RF generator/amplifier and a filter box were built. The possibility for simultaneous RF heating and MR thermal mapping of the system was confirmed in vitro using a phantom, and the obtained thermal mapping profile was compared with the simulated RF power distribution. Subsequently, the feasibility of simultaneous RF heating and temperature monitoring was successfully validated in vivo in the aorta of living rabbits. This MR imaging/RF heating system offers a potential tool for intravascular MR-mediated, RF-enhanced vascular gene therapy.

Original languageEnglish (US)
Pages (from-to)226-230
Number of pages5
JournalMagnetic resonance in medicine
Volume54
Issue number1
DOIs
StatePublished - Jul 2005

Keywords

  • Gene therapy
  • Intravascular MRI
  • MR imaging guide-wire
  • MR thermal mapping
  • Radiofrequency

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'Simultaneous radiofrequency (RF) heating and magnetic resonance (MR) thermal mapping using an intravascular MR imaging/RF heating system'. Together they form a unique fingerprint.

  • Cite this