Simultaneous Noninvasive Assessment of Systemic and Coronary Endothelial Function

Micaela Iantorno, Allison Hays, Michael Schar, Rupa Krishnaswamy, Sahar Soleimanifard, Angela Steinberg, Matthias Stuber, Gary Gerstenblith, Robert George Weiss

Research output: Contribution to journalArticle

Abstract

Background-Normal endothelial function is a measure of vascular health and dysfunction is a predictor of coronary events. Nitric oxide-mediated coronary artery endothelial function, as assessed by vasomotor reactivity during isometric handgrip exercise (IHE), was recently quantified noninvasively with magnetic resonance imaging (MRI). Because the internal mammary artery (IMA) is often visualized during coronary MRI, we propose the strategy of simultaneously assessing systemic and coronary endothelial function noninvasively by MRI during IHE. Methods and Results-Changes in cross-sectional area and blood flow in the right coronary artery and the IMA in 25 patients with coronary artery disease and 26 healthy subjects during IHE were assessed using 3T MRI. In 8 healthy subjects, a nitric oxide synthase inhibitor was infused to evaluate the role of nitric oxide in the IMA-IHE response. Interobserver IMA-IHE reproducibility was good for cross-sectional area (R=0.91) and blood flow (R=0.91). In healthy subjects, cross-sectional area and blood flow of the IMA increased during IHE, and these responses were significantly attenuated by monomethyl-l-arginine (P

Original languageEnglish (US)
Article numbere003954
JournalCirculation: Cardiovascular Imaging
Volume9
Issue number3
DOIs
StatePublished - Mar 1 2016

Fingerprint

Mammary Arteries
Exercise
Magnetic Resonance Imaging
Healthy Volunteers
Coronary Vessels
Nitric Oxide
Nitric Oxide Synthase
Blood Vessels
Arginine
Coronary Artery Disease
Health

Keywords

  • atherosclerosis
  • coronary artery disease
  • endothelium
  • magnetic resonance imaging
  • vasodilation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging

Cite this

Simultaneous Noninvasive Assessment of Systemic and Coronary Endothelial Function. / Iantorno, Micaela; Hays, Allison; Schar, Michael; Krishnaswamy, Rupa; Soleimanifard, Sahar; Steinberg, Angela; Stuber, Matthias; Gerstenblith, Gary; Weiss, Robert George.

In: Circulation: Cardiovascular Imaging, Vol. 9, No. 3, e003954, 01.03.2016.

Research output: Contribution to journalArticle

Iantorno, Micaela ; Hays, Allison ; Schar, Michael ; Krishnaswamy, Rupa ; Soleimanifard, Sahar ; Steinberg, Angela ; Stuber, Matthias ; Gerstenblith, Gary ; Weiss, Robert George. / Simultaneous Noninvasive Assessment of Systemic and Coronary Endothelial Function. In: Circulation: Cardiovascular Imaging. 2016 ; Vol. 9, No. 3.
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