Simultaneous monitoring of PET image resolution, noise, uniformity and quantitative accuracy using uniform cylinder phantom measurements in the multi-center setting

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We have proposed and implemented simultaneous monitoring of image resolution and noise, as well as image uniformity and quantitative accuracy, in a multi-center study of vascular dementia, only utilizing cylinder phantoms. Three centers were enrolled within the ARIC (Atherosclerosis Risk in Communities)-PET study involving amyloid imaging using F-18 Florbetapir. Weekly uniform phantom scans involving ∼1mCi of F-18 were conducted for the study duration in each of the three centers. The acquisition protocol consisted of 4×5min frames, consistent with the subject scans (4×5min, 50-70min post-injection). Image resolution was extracted by analyzing the blurring extent of the phantom edges. Specifically, the effective point-spread function (PSF) was obtained by taking the derivative of edges, followed by fitting with a Gaussian function. Noise was extracted by analysis of two back-to-back dynamic images, subtracted from one another, to remove the impact of any spatial non-uniformity, followed by computation of the standard deviation, which was then corrected by sqrt(2) given the difference operation. The phantom was also used to assess uniformity, using ratio of mean uptake within an inner circle to uptake within an outer annulus. Having knowledge of the exact dose, times of injection and scan, as well as phantom volume, enabled measurements of the true concentration, which in turn allowed assessment of quantitative accuracy. Our proposed framework enables feasible and routine multi-center monitoring of image quality, which also allowed us to arrive at a number of interesting observations and conclusions.

Original languageEnglish (US)
Title of host publication2014 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2014
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Print)9781479960972
DOIs
StatePublished - Mar 10 2016
EventIEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2014 - Seattle, United States
Duration: Nov 8 2014Nov 15 2014

Other

OtherIEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2014
CountryUnited States
CitySeattle
Period11/8/1411/15/14

Fingerprint

image resolution
Noise
Vascular Dementia
Injections
Amyloid
Atherosclerosis
injection
arteriosclerosis
blurring
annuli
point spread functions
nonuniformity
standard deviation
acquisition
dosage
florbetapir

ASJC Scopus subject areas

  • Nuclear and High Energy Physics
  • Radiology Nuclear Medicine and imaging

Cite this

Rahmim, A., Lodge, M., Crabb, A., Zhou, Y., Wong, D. F., & Gottesman, R. F. (2016). Simultaneous monitoring of PET image resolution, noise, uniformity and quantitative accuracy using uniform cylinder phantom measurements in the multi-center setting. In 2014 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2014 [7430840] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/NSSMIC.2014.7430840

Simultaneous monitoring of PET image resolution, noise, uniformity and quantitative accuracy using uniform cylinder phantom measurements in the multi-center setting. / Rahmim, A.; Lodge, Martin; Crabb, Andrew; Zhou, Yun; Wong, Dean Foster; Gottesman, Rebecca F.

2014 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2014. Institute of Electrical and Electronics Engineers Inc., 2016. 7430840.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Rahmim, A, Lodge, M, Crabb, A, Zhou, Y, Wong, DF & Gottesman, RF 2016, Simultaneous monitoring of PET image resolution, noise, uniformity and quantitative accuracy using uniform cylinder phantom measurements in the multi-center setting. in 2014 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2014., 7430840, Institute of Electrical and Electronics Engineers Inc., IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2014, Seattle, United States, 11/8/14. https://doi.org/10.1109/NSSMIC.2014.7430840
Rahmim A, Lodge M, Crabb A, Zhou Y, Wong DF, Gottesman RF. Simultaneous monitoring of PET image resolution, noise, uniformity and quantitative accuracy using uniform cylinder phantom measurements in the multi-center setting. In 2014 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2014. Institute of Electrical and Electronics Engineers Inc. 2016. 7430840 https://doi.org/10.1109/NSSMIC.2014.7430840
Rahmim, A. ; Lodge, Martin ; Crabb, Andrew ; Zhou, Yun ; Wong, Dean Foster ; Gottesman, Rebecca F. / Simultaneous monitoring of PET image resolution, noise, uniformity and quantitative accuracy using uniform cylinder phantom measurements in the multi-center setting. 2014 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2014. Institute of Electrical and Electronics Engineers Inc., 2016.
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