Simultaneous measurement of cerebral oxygen consumption and blood flow using 17O and 19F magnetic resonance imaging

James J Pekar, Teresa Sinnwell, Laszlo Ligeti, A. Scott Chesnick, Joseph A. Frank, Alan C. McLaughlin

Research output: Contribution to journalArticle

Abstract

17O and 19F magnetic resonance (MR) imaging were used to determine simultaneously the concentrations of H2 17O and CHF3 in 0.8-cc voxels in the cat brain during inhalation of a gas mixture containing both 17O2 and CHF3. The arterial time course of CHF3 was determined by "on-line" mass spectrometer detection of expired CHF3, and the arterial time course of H2 17O was determined by 17O MR analysis of arterial samples withdrawn during the inhalation period. The brain data and the arterial data for the two tracers were combined to calculate the cerebral oxygen consumption (CMRO2) and the CBF. The protocol was repeated on seven cats, using pentobarbital anesthesia. The average values of CMRO2 and CBF for a 0.8-cc voxel in the parietal cortex were 1.5 ± 0.5 mmol kg-1 min-1 and 38 ± 15 ml 100 g-1 min-1, respectively. In individual animals the average uncertainty in CMRO2 and CBF, calculated from Monte Carlo approaches, was ±9%.

Original languageEnglish (US)
Pages (from-to)312-320
Number of pages9
JournalJournal of Cerebral Blood Flow and Metabolism
Volume15
Issue number2
StatePublished - 1995
Externally publishedYes

Fingerprint

Oxygen Consumption
Magnetic Resonance Imaging
Inhalation
Cats
Parietal Lobe
Brain
Pentobarbital
Uncertainty
Magnetic Resonance Spectroscopy
Anesthesia
Gases
fluoroform

Keywords

  • O
  • F
  • Cerebral blood flow
  • Cerebral metabolic rate for oxygen
  • Nuclear magnetic resonance imaging
  • Tracer kinetics

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Neuroscience(all)

Cite this

Simultaneous measurement of cerebral oxygen consumption and blood flow using 17O and 19F magnetic resonance imaging. / Pekar, James J; Sinnwell, Teresa; Ligeti, Laszlo; Chesnick, A. Scott; Frank, Joseph A.; McLaughlin, Alan C.

In: Journal of Cerebral Blood Flow and Metabolism, Vol. 15, No. 2, 1995, p. 312-320.

Research output: Contribution to journalArticle

Pekar, James J ; Sinnwell, Teresa ; Ligeti, Laszlo ; Chesnick, A. Scott ; Frank, Joseph A. ; McLaughlin, Alan C. / Simultaneous measurement of cerebral oxygen consumption and blood flow using 17O and 19F magnetic resonance imaging. In: Journal of Cerebral Blood Flow and Metabolism. 1995 ; Vol. 15, No. 2. pp. 312-320.
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AU - Frank, Joseph A.

AU - McLaughlin, Alan C.

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