Simultaneous detection and separation of hyperacute intracerebral hemorrhage and cerebral ischemia using amide proton transfer MRI

Meiyun Wang, Xiaohua Hong, Che Feng Chang, Qiang Li, Bo Ma, Hong Zhang, Sinan Xiang, Hye Young Heo, Yi Zhang, Dong Hoon Lee, Shanshan Jiang, Richard Leigh, Raymond C. Koehler, Peter C.M. Van Zijl, Jian Wang, Jinyuan Zhou

Research output: Contribution to journalArticle

Abstract

Purpose To explore the capability of amide proton transfer (APT) imaging in the detection of hemorrhagic and ischemic strokes using preclinical rat models. Methods The rat intracerebral hemorrhage (ICH) model (n = 10) was induced by injecting bacterial collagenase VII-S into the caudate nucleus, and the permanent ischemic stroke model (n = 10) was induced by using a 4-0 nylon suture to occlude the origin of the middle cerebral artery. APT-weighted (APTw) MRI was acquired on a 4.7T animal imager and quantified using the magnetization transfer-ratio asymmetry at 3.5 ppm from water. Results There was a consistently high APTw MRI signal in hyperacute ICH during the initial 12 h after injection of collagenase compared with the contralateral brain tissue. When hemorrhagic and ischemic stroke were compared, hyperacute ICH and cerebral ischemia demonstrated opposite APTw MRI contrasts - namely, hyperintense versus hypointense compared with contralateral brain tissue, respectively. There was a stark contrast in APTw signal intensity between these two lesions. Conclusion APT-MRI could accurately detect hyperacute ICH and distinctly differentiate hyperacute ICH from cerebral ischemia, thus opening up the possibility of introducing to the clinic a single MRI scan for the simultaneous visualization and separation of hemorrhagic and ischemic strokes at the hyperacute stage. Magn Reson Med 74:42-50, 2015.

Original languageEnglish (US)
Pages (from-to)42-50
Number of pages9
JournalMagnetic resonance in medicine
Volume74
Issue number1
DOIs
StatePublished - Jul 1 2015

Keywords

  • APT imaging
  • CEST imaging
  • intracerebral hemorrhage
  • molecular imaging
  • stroke

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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