Simultaneous 99mTc/201Tl/123i triple-isotope cardiac SPECT imaging

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Multiple isotope simultaneous acquisition SPECT imaging can provide spatially and temporally registered images with just one image acquisition. We have previously demonstrated that, with model-based crosstalk compensation, simultaneously acquired 99mTc/201Tl dual-isotope cardiac imaging can provide images with quality and quantitative accuracy that is comparable with that from separate acquisition. Given the capability of modern SPECT systems to acquire projections in multiple energy windows, it is potentially possible to simultaneously assess rest and stress perfusion status with 201Tl and a 99mTc labeled agent, and innervation status with 123I-MIBG. However, because these three isotopes have very close emission energies and energy windows, crosstalk contamination can severely degrade the quality of simultaneously acquired images. In this work we developed a model-based method for estimating and compensating for the crosstalk and downscatter contamination in simultaneously acquired triple-isotope images. The crosstalk model includes the effects of the photon interactions inside the object and collimator-detector system. This crosstalk model was incorporated into the forward projection step of an iterative reconstruction algorithm to provide crosstalk compensation. We evaluated the proposed model-based method using Monte Carlo simulated simultaneous triple-isotope projection data. Results showed that there was very good agreement between the model-based estimates and the MC simulated projection data in each of the isotopes' energy windows. After compensation, the crosstalk in the simultaneously acquired images was effectively removed. In conclusion, we showed that it is possible to simultaneously acquire the cardiac SPECT imaging with 99mTc/ 201Tl/123I labeled multiple tracers. Using the proposed model-based crosstalk compensation method, the qualities of the simultaneously acquired triple-isotope images were comparable with the single acquisitions.

Original languageEnglish (US)
Title of host publicationIEEE Nuclear Science Symposium Conference Record
Pages4213-4216
Number of pages4
Volume6
DOIs
StatePublished - 2007
Event2007 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS-MIC - Honolulu, HI, United States
Duration: Oct 27 2007Nov 3 2007

Other

Other2007 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS-MIC
CountryUnited States
CityHonolulu, HI
Period10/27/0711/3/07

Fingerprint

Crosstalk
Isotopes
Imaging techniques
Contamination
Image acquisition
Monte Carlo methods
Photons
Detectors
Compensation and Redress

ASJC Scopus subject areas

  • Computer Vision and Pattern Recognition
  • Industrial and Manufacturing Engineering

Cite this

Du, Y., & Frey, E. (2007). Simultaneous 99mTc/201Tl/123i triple-isotope cardiac SPECT imaging. In IEEE Nuclear Science Symposium Conference Record (Vol. 6, pp. 4213-4216). [4437047] https://doi.org/10.1109/NSSMIC.2007.4437047

Simultaneous 99mTc/201Tl/123i triple-isotope cardiac SPECT imaging. / Du, Yong; Frey, Eric.

IEEE Nuclear Science Symposium Conference Record. Vol. 6 2007. p. 4213-4216 4437047.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Du, Y & Frey, E 2007, Simultaneous 99mTc/201Tl/123i triple-isotope cardiac SPECT imaging. in IEEE Nuclear Science Symposium Conference Record. vol. 6, 4437047, pp. 4213-4216, 2007 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS-MIC, Honolulu, HI, United States, 10/27/07. https://doi.org/10.1109/NSSMIC.2007.4437047
Du Y, Frey E. Simultaneous 99mTc/201Tl/123i triple-isotope cardiac SPECT imaging. In IEEE Nuclear Science Symposium Conference Record. Vol. 6. 2007. p. 4213-4216. 4437047 https://doi.org/10.1109/NSSMIC.2007.4437047
Du, Yong ; Frey, Eric. / Simultaneous 99mTc/201Tl/123i triple-isotope cardiac SPECT imaging. IEEE Nuclear Science Symposium Conference Record. Vol. 6 2007. pp. 4213-4216
@inproceedings{e19bc673995c40a78ee45b1bfdd3ff96,
title = "Simultaneous 99mTc/201Tl/123i triple-isotope cardiac SPECT imaging",
abstract = "Multiple isotope simultaneous acquisition SPECT imaging can provide spatially and temporally registered images with just one image acquisition. We have previously demonstrated that, with model-based crosstalk compensation, simultaneously acquired 99mTc/201Tl dual-isotope cardiac imaging can provide images with quality and quantitative accuracy that is comparable with that from separate acquisition. Given the capability of modern SPECT systems to acquire projections in multiple energy windows, it is potentially possible to simultaneously assess rest and stress perfusion status with 201Tl and a 99mTc labeled agent, and innervation status with 123I-MIBG. However, because these three isotopes have very close emission energies and energy windows, crosstalk contamination can severely degrade the quality of simultaneously acquired images. In this work we developed a model-based method for estimating and compensating for the crosstalk and downscatter contamination in simultaneously acquired triple-isotope images. The crosstalk model includes the effects of the photon interactions inside the object and collimator-detector system. This crosstalk model was incorporated into the forward projection step of an iterative reconstruction algorithm to provide crosstalk compensation. We evaluated the proposed model-based method using Monte Carlo simulated simultaneous triple-isotope projection data. Results showed that there was very good agreement between the model-based estimates and the MC simulated projection data in each of the isotopes' energy windows. After compensation, the crosstalk in the simultaneously acquired images was effectively removed. In conclusion, we showed that it is possible to simultaneously acquire the cardiac SPECT imaging with 99mTc/ 201Tl/123I labeled multiple tracers. Using the proposed model-based crosstalk compensation method, the qualities of the simultaneously acquired triple-isotope images were comparable with the single acquisitions.",
author = "Yong Du and Eric Frey",
year = "2007",
doi = "10.1109/NSSMIC.2007.4437047",
language = "English (US)",
isbn = "1424409233",
volume = "6",
pages = "4213--4216",
booktitle = "IEEE Nuclear Science Symposium Conference Record",

}

TY - GEN

T1 - Simultaneous 99mTc/201Tl/123i triple-isotope cardiac SPECT imaging

AU - Du, Yong

AU - Frey, Eric

PY - 2007

Y1 - 2007

N2 - Multiple isotope simultaneous acquisition SPECT imaging can provide spatially and temporally registered images with just one image acquisition. We have previously demonstrated that, with model-based crosstalk compensation, simultaneously acquired 99mTc/201Tl dual-isotope cardiac imaging can provide images with quality and quantitative accuracy that is comparable with that from separate acquisition. Given the capability of modern SPECT systems to acquire projections in multiple energy windows, it is potentially possible to simultaneously assess rest and stress perfusion status with 201Tl and a 99mTc labeled agent, and innervation status with 123I-MIBG. However, because these three isotopes have very close emission energies and energy windows, crosstalk contamination can severely degrade the quality of simultaneously acquired images. In this work we developed a model-based method for estimating and compensating for the crosstalk and downscatter contamination in simultaneously acquired triple-isotope images. The crosstalk model includes the effects of the photon interactions inside the object and collimator-detector system. This crosstalk model was incorporated into the forward projection step of an iterative reconstruction algorithm to provide crosstalk compensation. We evaluated the proposed model-based method using Monte Carlo simulated simultaneous triple-isotope projection data. Results showed that there was very good agreement between the model-based estimates and the MC simulated projection data in each of the isotopes' energy windows. After compensation, the crosstalk in the simultaneously acquired images was effectively removed. In conclusion, we showed that it is possible to simultaneously acquire the cardiac SPECT imaging with 99mTc/ 201Tl/123I labeled multiple tracers. Using the proposed model-based crosstalk compensation method, the qualities of the simultaneously acquired triple-isotope images were comparable with the single acquisitions.

AB - Multiple isotope simultaneous acquisition SPECT imaging can provide spatially and temporally registered images with just one image acquisition. We have previously demonstrated that, with model-based crosstalk compensation, simultaneously acquired 99mTc/201Tl dual-isotope cardiac imaging can provide images with quality and quantitative accuracy that is comparable with that from separate acquisition. Given the capability of modern SPECT systems to acquire projections in multiple energy windows, it is potentially possible to simultaneously assess rest and stress perfusion status with 201Tl and a 99mTc labeled agent, and innervation status with 123I-MIBG. However, because these three isotopes have very close emission energies and energy windows, crosstalk contamination can severely degrade the quality of simultaneously acquired images. In this work we developed a model-based method for estimating and compensating for the crosstalk and downscatter contamination in simultaneously acquired triple-isotope images. The crosstalk model includes the effects of the photon interactions inside the object and collimator-detector system. This crosstalk model was incorporated into the forward projection step of an iterative reconstruction algorithm to provide crosstalk compensation. We evaluated the proposed model-based method using Monte Carlo simulated simultaneous triple-isotope projection data. Results showed that there was very good agreement between the model-based estimates and the MC simulated projection data in each of the isotopes' energy windows. After compensation, the crosstalk in the simultaneously acquired images was effectively removed. In conclusion, we showed that it is possible to simultaneously acquire the cardiac SPECT imaging with 99mTc/ 201Tl/123I labeled multiple tracers. Using the proposed model-based crosstalk compensation method, the qualities of the simultaneously acquired triple-isotope images were comparable with the single acquisitions.

UR - http://www.scopus.com/inward/record.url?scp=48149096728&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=48149096728&partnerID=8YFLogxK

U2 - 10.1109/NSSMIC.2007.4437047

DO - 10.1109/NSSMIC.2007.4437047

M3 - Conference contribution

AN - SCOPUS:48149096728

SN - 1424409233

SN - 9781424409235

VL - 6

SP - 4213

EP - 4216

BT - IEEE Nuclear Science Symposium Conference Record

ER -