Abstract
We have created a 2-dimensional model of cardiac tissue in order to study the distribution of the transmembrane potential after stimulation with a circular extracellular electrode. The tissue is modeled as a collection of uncoupled fibers, and the fibers are discretized into elements with active Luo-Rudy kinetics. We assume that gradients in the extracellular potential drive the membrane, and we use an S1-S2 protocol to determine the tissue response during the absolute refractory period. We see that: 1) the Vm isopotential lines from a 'dog-bone' shape, as other models predict, 2) in the longitudinal direction the response reverses polarity (virtual electrode effect), while in the transverse direction the polarity does not change, 3) the responses to anodal and cathodal electrodes are not symmetric, and 4) the location of the point of reversal depends on the polarity of the pulse. These last two results have been reported in recent experiments.
Original language | English (US) |
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Pages (from-to) | 65-66 |
Number of pages | 2 |
Journal | Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings |
Volume | 16 |
Issue number | pt 1 |
State | Published - 1994 |
Event | Proceedings of the 16th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Part 1 (of 2) - Baltimore, MD, USA Duration: Nov 3 1994 → Nov 6 1994 |
ASJC Scopus subject areas
- Signal Processing
- Biomedical Engineering
- Computer Vision and Pattern Recognition
- Health Informatics