Simulations of the transmembrane potential distribution around an extracellular electrode in an active 2-D sheet of cardiac tissue

Eric A. Sobie, Leslie Tung

Research output: Contribution to journalConference articlepeer-review

Abstract

We have created a 2-dimensional model of cardiac tissue in order to study the distribution of the transmembrane potential after stimulation with a circular extracellular electrode. The tissue is modeled as a collection of uncoupled fibers, and the fibers are discretized into elements with active Luo-Rudy kinetics. We assume that gradients in the extracellular potential drive the membrane, and we use an S1-S2 protocol to determine the tissue response during the absolute refractory period. We see that: 1) the Vm isopotential lines from a 'dog-bone' shape, as other models predict, 2) in the longitudinal direction the response reverses polarity (virtual electrode effect), while in the transverse direction the polarity does not change, 3) the responses to anodal and cathodal electrodes are not symmetric, and 4) the location of the point of reversal depends on the polarity of the pulse. These last two results have been reported in recent experiments.

Original languageEnglish (US)
Pages (from-to)65-66
Number of pages2
JournalAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume16
Issue numberpt 1
StatePublished - Dec 1 1994
EventProceedings of the 16th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Part 1 (of 2) - Baltimore, MD, USA
Duration: Nov 3 1994Nov 6 1994

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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