Simulations of electrical field stimulation of cardiac myocytes during the relative refractory period

Leslie Tung, Sandeep K. Jain

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Global stimulation of the heart during defibrillation may be the result of local field stimulation at the cellular level, in which one end of the cell is depolarized while the other end is hyperpolarized. We have formulated a model which describes the spatial and temporal variation of transmembrane potential along the surface membrane of a single cell subjected to a spatially uniform, pulsed electric field. The ability of the applied field to prolong the action potential may be a relevant factor during defibrillation, and we have used the model to determine the extent of prolongation when the waveform is applied during repolarization. Using an S1-S2 protocol, we find that despite the complicated membrane response, 5 msec, rectangular monophasic S2 pulses (with intensity 2.5 times the SI threshold) prolong the action potential as a monotonie function of the Sl-S2 interval. This finding is similar to cellular responses to stimulation by intracellular current injection.

Original languageEnglish (US)
Title of host publicationProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 1992
EditorsRobert Plonsey, Jean Louis Coatrieux, Swamy Laxminarayan, Jean Pierre Morucci
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages644-645
Number of pages2
ISBN (Electronic)0780307852
DOIs
StatePublished - Jan 1 1992
Event14th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 1992 - Paris, France
Duration: Oct 29 1992Nov 1 1992

Publication series

NameProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
Volume2
ISSN (Print)1557-170X

Conference

Conference14th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 1992
CountryFrance
CityParis
Period10/29/9211/1/92

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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  • Cite this

    Tung, L., & Jain, S. K. (1992). Simulations of electrical field stimulation of cardiac myocytes during the relative refractory period. In R. Plonsey, J. L. Coatrieux, S. Laxminarayan, & J. P. Morucci (Eds.), Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 1992 (pp. 644-645). [5761151] (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS; Vol. 2). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/IEMBS.1992.5761151