Simulation study of the effect of pinacidil on ATP-sensitive potassium current and action potential duration in myocardial tissue

Metabolic impairment and potassium channel openers, such as pinacidil, activate the ATP-sensitive potassium current [I_K(ATP)]. This effect leads to a reduction of action potential duration (APD), eliciting serious arrhythmias, and reentry. However, the arrhythmogenic effects of the activation of I_K(ATP) should be further studied. Our goal is to simulate the effects of pinacidil on APD shortening with the aid of a computer model. This model is based on experimental results of the effects of pinacidil on I_K(ATP) and its voltage dependence. The mathematical formulation completed the I_K(ATP) model by Ferrero et al., which was introduced into the ventricular cardiac action potential model described by Luo and Rudy (phase II). The results of the simulations correlate well with experimentally estimated values and show that pinacidil strongly affects APD. Further simulations could elucidate the proarrhythmic or antiarrhythmic effects of pinacidil in myocardial tissue.