Simulation study of action potentials from metabolically impaired cardiac myocytes

J. M. Ferrero, J. Saiz, J. M. Ferrero, L. M. Roa, N. V. Thakor

Research output: Contribution to journalConference article

Abstract

The aim of this work is to quantitatively study the role of the ATP-sensitive potassium current (IK-ATP) and its contribution to the electrophysiological changes which occur during metabolic impairment in ventricular cardiac myocytes. For this purpose, we have formulated a model of the IK-ATP current and incorporated it into the Luo-Rudy model of the ventricular cardiac action potential. We simulated action potentials (AP) developed by space-clamped myocytes under different intracellular levels of ATP and ADP. At normal ionic concentrations, only approx.0.6% of the channels, when open, accounted for a 50% reduction in AP duration. Increased levels of intracellular Mg2+ counteract this shortening, while high extracellular potassium has the opposite effect. Our theoretical results show that opening of IK-ATP channels plays a significant role in AP shortening during hypoxic/ischemic episodes, with the fraction of open channels involved being very low (less than 1%).

Original languageEnglish (US)
Pages (from-to)47-50
Number of pages4
JournalComputers in cardiology
StatePublished - Dec 1 1995
EventProceedings of the 1995 Conference on Computers in Cardiology - Vienna, Austria
Duration: Sep 10 1995Sep 13 1995

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ASJC Scopus subject areas

  • Computer Science Applications
  • Cardiology and Cardiovascular Medicine

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