Abstract
The goal of this work is to theoretically study the effect of cellular coupling on generation of triggered activity and abnormal automaticity in cardiac ventricular myocytes. We have used a computer model of the ventricular action potential in a system of two cells coupled by a resistance R. With [Ca]i=0.5μM, the spontaneous activity varies from two action potentials followed by three DADs at R=10M Ω to eight action potentials for complete uncoupling. Under EAD conditions, EADs appear on the AP plateau for complete uncoupling, thus provoking lengthening. When the value of R is decreased, the APD becames substantially shortened. However, at a value of R for which the action potential is propagated a prolongation of APD is again produced. Therefore, the coupling resistance may affect triggered activity and abnormal automatically formation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 345-348 |
| Number of pages | 4 |
| Journal | Computers in cardiology |
| State | Published - 1995 |
| Externally published | Yes |
| Event | Proceedings of the 1995 Conference on Computers in Cardiology - Vienna, Austria Duration: Sep 10 1995 → Sep 13 1995 |
ASJC Scopus subject areas
- Computer Science Applications
- Cardiology and Cardiovascular Medicine