Simulation of tissue atrophy using a topology preserving transformation model

Bilge Karaçali, Christos Davatzikos

Research output: Contribution to journalArticlepeer-review

52 Scopus citations


We propose a method to simulate atrophy and other similar volumetric change effects on medical images. Given a desired level of atrophy, we find a dense warping deformation that produces the corresponding levels of volumetric loss on the labeled tissue using an energy minimization strategy. Simulated results on a real brain image indicate that the method generates realistic images of tissue loss. The method does not make assumptions regarding the mechanics of tissue deformation, and provides a framework where a pre-specifled pattern of atrophy can readily be simulated. Furthermore, it provides exact correspondences between images prior and posterior to the atrophy that can be used to evaluate provisional image registration and atrophy quantification algorithms.

Original languageEnglish (US)
Pages (from-to)649-652
Number of pages4
JournalIEEE transactions on medical imaging
Issue number5
StatePublished - May 2006
Externally publishedYes

ASJC Scopus subject areas

  • Software
  • Radiological and Ultrasound Technology
  • Computer Science Applications
  • Electrical and Electronic Engineering


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