Simplified detection system for neuroreceptor studies in the human brain

A. N. Bice, H. N. Wagner, J. J. Frost, T. K. Natarajan, M. C. Lee, D. F. Wong, R. F. Dannals, H. T. Ravert, A. A. Wilson, J. M. Links

Research output: Contribution to journalArticlepeer-review

Abstract

A simple, inexpensive dual-detector system has been developed for measurement of positron-emitting receptor-binding drugs in the human brain. This high efficiency coincidence counting system requires that only a few hundred microcuries of labeled drug be administered to the subject, thereby allowing for multiple studies without an excessive radiation dose. Measurement of the binding of [11C]carfentanil, a high affinity synthetic opiate, to opiate receptors in the presence and in the absence of a competitive opiate antagonist indicates that potential utility of this system for estimating different degrees of receptor occupation in the human brain.

Original languageEnglish (US)
Pages (from-to)184-191
Number of pages8
JournalJournal of Nuclear Medicine
Volume27
Issue number2
StatePublished - Dec 1 1986

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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