Abstract
When the tricyclic moiety of himbacine is replaced with a dihydroanthracene nucleaus, an increase in affinity at both M1 and M2 receptors subtypes is observed. Other modifications to the himbacine skeleton were examined and the new structures tested for potency and selectivity at M1 and M2 sites.
Original language | English (US) |
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Pages (from-to) | 1247-1252 |
Number of pages | 6 |
Journal | Bioorganic and Medicinal Chemistry Letters |
Volume | 3 |
Issue number | 6 |
DOIs | |
State | Published - Jun 1993 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry