Simplified analogs of himbacine displaying potent binding affinity for muscarinic receptors

Michael J. Malaska, Abdul H. Fauq, Alan P. Kozikowski, Patricia J. Aagaard, Michael McKinney

Research output: Contribution to journalArticle

Abstract

When the tricyclic moiety of himbacine is replaced with a dihydroanthracene nucleaus, an increase in affinity at both M1 and M2 receptors subtypes is observed. Other modifications to the himbacine skeleton were examined and the new structures tested for potency and selectivity at M1 and M2 sites.

Original languageEnglish (US)
Pages (from-to)1247-1252
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume3
Issue number6
DOIs
StatePublished - 1993
Externally publishedYes

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Muscarinic Receptors
Skeleton
himbacine

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Simplified analogs of himbacine displaying potent binding affinity for muscarinic receptors. / Malaska, Michael J.; Fauq, Abdul H.; Kozikowski, Alan P.; Aagaard, Patricia J.; McKinney, Michael.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 3, No. 6, 1993, p. 1247-1252.

Research output: Contribution to journalArticle

Malaska, Michael J. ; Fauq, Abdul H. ; Kozikowski, Alan P. ; Aagaard, Patricia J. ; McKinney, Michael. / Simplified analogs of himbacine displaying potent binding affinity for muscarinic receptors. In: Bioorganic and Medicinal Chemistry Letters. 1993 ; Vol. 3, No. 6. pp. 1247-1252.
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