TY - JOUR
T1 - Simple numeric abnormalities as primary karyotype changes in ovarian carcinoma
AU - Thompson, Floyd H.
AU - Liu, Yun
AU - Emerson, Julia
AU - Weinstein, Ronald
AU - Makar, Rosemary
AU - Trent, Jeffrey M.
AU - Taetle, Raymond
AU - Alberts, David S.
PY - 1994/8
Y1 - 1994/8
N2 - Simple near‐diploid karyotypes in ovarian cancer may indicate either primary alterations related to tumor pathogenesis or abnormalities associated with early tumor progression. We have identified a series of 13 epithelial ovarian tumors with very simple karyotypes. Specifically, these karyotypes were near‐diploid and displayed numeric abnormalities alone or combined with one or two structural alterations. The present series includes samples from 10 patients with newly diagnosed adenocarcinomas and 3 patients having borderline malignancies. Recurrent numeric abnormalities were identified and included 9/13 cases (69%) with + 12, eight cases (62%) with + 8, five cases (38%) with + 7, three cases (23%) each with + 3 or + 5, and two cases (15%) with ‐X, Five cases in this series displayed certain numeric abnormalities (+ 12, + 7, and ‐X) as the sole anomalies, thereby qualifying as primary karyotype changes. Of the 6 cases with structural abnormalities, 4 involved chromosome 19, 2 involved chromosome I, and the remaining abnormalities or translocation partners involved other chromosomes. These findings indicate that some numeric abnormalities are primary karyotype alterations in patients with malignant epithelial ovarian tumors and that chromosome 19 may be preferentially involved in structural rearrangements during early tumor progression. Genes Chromosom Cancer 10:262–266 (1994). © 1994 Wiley‐Liss, Inc.
AB - Simple near‐diploid karyotypes in ovarian cancer may indicate either primary alterations related to tumor pathogenesis or abnormalities associated with early tumor progression. We have identified a series of 13 epithelial ovarian tumors with very simple karyotypes. Specifically, these karyotypes were near‐diploid and displayed numeric abnormalities alone or combined with one or two structural alterations. The present series includes samples from 10 patients with newly diagnosed adenocarcinomas and 3 patients having borderline malignancies. Recurrent numeric abnormalities were identified and included 9/13 cases (69%) with + 12, eight cases (62%) with + 8, five cases (38%) with + 7, three cases (23%) each with + 3 or + 5, and two cases (15%) with ‐X, Five cases in this series displayed certain numeric abnormalities (+ 12, + 7, and ‐X) as the sole anomalies, thereby qualifying as primary karyotype changes. Of the 6 cases with structural abnormalities, 4 involved chromosome 19, 2 involved chromosome I, and the remaining abnormalities or translocation partners involved other chromosomes. These findings indicate that some numeric abnormalities are primary karyotype alterations in patients with malignant epithelial ovarian tumors and that chromosome 19 may be preferentially involved in structural rearrangements during early tumor progression. Genes Chromosom Cancer 10:262–266 (1994). © 1994 Wiley‐Liss, Inc.
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U2 - 10.1002/gcc.2870100407
DO - 10.1002/gcc.2870100407
M3 - Article
C2 - 7522540
AN - SCOPUS:0028025495
SN - 1045-2257
VL - 10
SP - 262
EP - 266
JO - Genes, Chromosomes and Cancer
JF - Genes, Chromosomes and Cancer
IS - 4
ER -