SIMPLE INSTRUMENT FOR BIOCHEMICAL STUDIES OF THE LIVING HUMAN BRAIN.

Alden N. Bice, Henry N. Wagner, Myung C. Lee, J. James Frost

Research output: Contribution to journalArticle

Abstract

A simple, relatively inexpensive radiation detection system was developed for measurement of positron-emitting receptor-binding drugs in the human brain. This high-efficiency coincidence counting system requires that only a few hundred microcuries of labeled drug be administered to the subject, thereby allowing for multiple studies without an excessive radiation dose. Measurement of the binding of left bracket **1**1C right bracket -carfentanil, a high-affinity synthetic opiate, to opiate receptors in the presence and in the absence of a competitive opiate antagonist exemplifies the use of this system for estimating different degrees of receptor binding of drugs in the human brain. The instrument has also been used for measurement of the transport into the brain of other positron-emitting radiotracers, such as large neutral amino acids.

Original languageEnglish (US)
Pages (from-to)244-247
Number of pages4
JournalMedical Instrumentation
Volume20
Issue number5
StatePublished - Sep 1986

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)

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    Bice, A. N., Wagner, H. N., Lee, M. C., & Frost, J. J. (1986). SIMPLE INSTRUMENT FOR BIOCHEMICAL STUDIES OF THE LIVING HUMAN BRAIN. Medical Instrumentation, 20(5), 244-247.