Similarity of synthetic peptide from human tumor to parathyroid hormone in vivo and in vitro

Noboru Horiuchi, Mlchael P. Caulfield, John E. Fisher, Mark E. Goldman, Roberta L. McKee, Jane E. Reagan, Jay J. Levy, Ruth F. Nutt, Sevgi B. Rodan, Timothy L. Schofield, Thomas L. Clemens, Michael Rosenblatt

Research output: Contribution to journalArticlepeer-review

Abstract

One mechanism considered responsible for the hypercalcemia that frequently accompanies malignancy is secretion by the tumor of a circulating factor that alters calcium metabolism. The structure of a tumor-secreted peptide was recently determined and found to be partially homologous to parathyroid hormone (PTH). The aminoterminal 1-34 region of the factor was synthesized and evaluated biologically. In vivo it produced hypercalcemia, acted on bone and kidney, and stimulated 1,25-dihydroxyvitamin D3 formation. In vitro it interacted with PTH receptors and, in some systems, was more potent than PTH. These studies support a long-standing hypothesis regarding pathogenesis of malignancy-associated hypercalcemia.

Original languageEnglish (US)
Pages (from-to)1566-1568
Number of pages3
JournalScience
Volume238
Issue number4833
DOIs
StatePublished - 1987
Externally publishedYes

ASJC Scopus subject areas

  • General

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