Similarity of DNA fingerprints due to chance and relatedness

C. C. Li; B. E. Weeks; A. Chakravarti

doi:10.1159/000154113

Similarity of DNA fingerprints due to chance and relatedness

C. C. Li, B. E. Weeks, A. Chakravarti

School of Medicine

Research output: Contribution to journal › Article › peer-review

190 Scopus citations

Abstract

Given the DNA fingerprints of two individuals with some bands being shared by both individuals, we define a new measure of the degree of similarity between the DNA profiles of two individuals. We use this measure to calculate the expected DNA similarity of two unrelated individuals of a randomly mating population; this similarity is due to chance only. Then, the expected similarity between two related individuals is obtained; this similarity is due to chance and relatedness. From these results, the degree of similarity due to relatedness alone may be calculated.

Original language	English (US)
Pages (from-to)	45-52
Number of pages	8
Journal	Human Heredity
Volume	43
Issue number	1
DOIs	https://doi.org/10.1159/000154113
State	Published - Jan 1 1993

Keywords

Coefficient of relationship
DNA fingerprints
Population genetics
Relatedness

ASJC Scopus subject areas

Genetics
Genetics(clinical)

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abstract = "Given the DNA fingerprints of two individuals with some bands being shared by both individuals, we define a new measure of the degree of similarity between the DNA profiles of two individuals. We use this measure to calculate the expected DNA similarity of two unrelated individuals of a randomly mating population; this similarity is due to chance only. Then, the expected similarity between two related individuals is obtained; this similarity is due to chance and relatedness. From these results, the degree of similarity due to relatedness alone may be calculated.",

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AU - Weeks, B. E.

AU - Chakravarti, A.

PY - 1993/1/1

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N2 - Given the DNA fingerprints of two individuals with some bands being shared by both individuals, we define a new measure of the degree of similarity between the DNA profiles of two individuals. We use this measure to calculate the expected DNA similarity of two unrelated individuals of a randomly mating population; this similarity is due to chance only. Then, the expected similarity between two related individuals is obtained; this similarity is due to chance and relatedness. From these results, the degree of similarity due to relatedness alone may be calculated.

AB - Given the DNA fingerprints of two individuals with some bands being shared by both individuals, we define a new measure of the degree of similarity between the DNA profiles of two individuals. We use this measure to calculate the expected DNA similarity of two unrelated individuals of a randomly mating population; this similarity is due to chance only. Then, the expected similarity between two related individuals is obtained; this similarity is due to chance and relatedness. From these results, the degree of similarity due to relatedness alone may be calculated.

KW - Coefficient of relationship

KW - DNA fingerprints

KW - Population genetics

KW - Relatedness

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Similarity of DNA fingerprints due to chance and relatedness

Abstract

Keywords

ASJC Scopus subject areas

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