Similarities and differences in arterial responses to hypercapnia and visual stimulation

Yi Ching Lynn Ho, Esben Thade Petersen, Ivan Zimine, Xavier Golay

Research output: Contribution to journalArticle

Abstract

Despite the different origins of cerebrovascular activity induced by neurogenic and nonneurogenic conditions, a standard assumption in functional studies is that the consequence on the vascular system will be mechanically similar. Using a recently developed arterial spin labeling method, we examined arterial blood volume, arterial-microvascular transit time, and cerebral blood flow (CBF) in the gray matter and in areas with large arterial vessels under hypercapnia, visual stimulation, and a combination of the two. Spatial heterogeneity in arterial reactivity was observed between conditions. During hypercapnia, large arterial volume changes contributed to CBF increase and further downstream, there were reductions in the gray matter transit time. These changes were not significant during visual stimulation, and during the combined condition they were moderated. These findings suggest distinct vascular mechanisms for large and small arterial segments that may be condition specific. However, the power relationships between gray matter arterial blood volume and CBF in hypercapnia (α0.690.24) and visual stimulation (α0.680.20) were similar. Assuming consistent capillary and venous volume responses across these conditions, these results offer support for a consistent total CBV-flow relationship typically assumed in blood oxygen-level dependent calibration techniques.

Original languageEnglish (US)
Pages (from-to)560-571
Number of pages12
JournalJournal of Cerebral Blood Flow and Metabolism
Volume31
Issue number2
DOIs
StatePublished - Feb 2011
Externally publishedYes

Fingerprint

Cerebrovascular Circulation
Photic Stimulation
Hypercapnia
Blood Volume
Blood Vessels
Calibration
Oxygen
Gray Matter

Keywords

  • cerebral blood flow
  • cerebral hemodynamics
  • experimental
  • functional MRI
  • neurophysiology

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Neurology

Cite this

Similarities and differences in arterial responses to hypercapnia and visual stimulation. / Ho, Yi Ching Lynn; Petersen, Esben Thade; Zimine, Ivan; Golay, Xavier.

In: Journal of Cerebral Blood Flow and Metabolism, Vol. 31, No. 2, 02.2011, p. 560-571.

Research output: Contribution to journalArticle

Ho, Yi Ching Lynn ; Petersen, Esben Thade ; Zimine, Ivan ; Golay, Xavier. / Similarities and differences in arterial responses to hypercapnia and visual stimulation. In: Journal of Cerebral Blood Flow and Metabolism. 2011 ; Vol. 31, No. 2. pp. 560-571.
@article{a3cdcc2a8d374cfcb5e9973c8aeaff38,
title = "Similarities and differences in arterial responses to hypercapnia and visual stimulation",
abstract = "Despite the different origins of cerebrovascular activity induced by neurogenic and nonneurogenic conditions, a standard assumption in functional studies is that the consequence on the vascular system will be mechanically similar. Using a recently developed arterial spin labeling method, we examined arterial blood volume, arterial-microvascular transit time, and cerebral blood flow (CBF) in the gray matter and in areas with large arterial vessels under hypercapnia, visual stimulation, and a combination of the two. Spatial heterogeneity in arterial reactivity was observed between conditions. During hypercapnia, large arterial volume changes contributed to CBF increase and further downstream, there were reductions in the gray matter transit time. These changes were not significant during visual stimulation, and during the combined condition they were moderated. These findings suggest distinct vascular mechanisms for large and small arterial segments that may be condition specific. However, the power relationships between gray matter arterial blood volume and CBF in hypercapnia (α0.690.24) and visual stimulation (α0.680.20) were similar. Assuming consistent capillary and venous volume responses across these conditions, these results offer support for a consistent total CBV-flow relationship typically assumed in blood oxygen-level dependent calibration techniques.",
keywords = "cerebral blood flow, cerebral hemodynamics, experimental, functional MRI, neurophysiology",
author = "Ho, {Yi Ching Lynn} and Petersen, {Esben Thade} and Ivan Zimine and Xavier Golay",
year = "2011",
month = "2",
doi = "10.1038/jcbfm.2010.126",
language = "English (US)",
volume = "31",
pages = "560--571",
journal = "Journal of Cerebral Blood Flow and Metabolism",
issn = "0271-678X",
publisher = "Nature Publishing Group",
number = "2",

}

TY - JOUR

T1 - Similarities and differences in arterial responses to hypercapnia and visual stimulation

AU - Ho, Yi Ching Lynn

AU - Petersen, Esben Thade

AU - Zimine, Ivan

AU - Golay, Xavier

PY - 2011/2

Y1 - 2011/2

N2 - Despite the different origins of cerebrovascular activity induced by neurogenic and nonneurogenic conditions, a standard assumption in functional studies is that the consequence on the vascular system will be mechanically similar. Using a recently developed arterial spin labeling method, we examined arterial blood volume, arterial-microvascular transit time, and cerebral blood flow (CBF) in the gray matter and in areas with large arterial vessels under hypercapnia, visual stimulation, and a combination of the two. Spatial heterogeneity in arterial reactivity was observed between conditions. During hypercapnia, large arterial volume changes contributed to CBF increase and further downstream, there were reductions in the gray matter transit time. These changes were not significant during visual stimulation, and during the combined condition they were moderated. These findings suggest distinct vascular mechanisms for large and small arterial segments that may be condition specific. However, the power relationships between gray matter arterial blood volume and CBF in hypercapnia (α0.690.24) and visual stimulation (α0.680.20) were similar. Assuming consistent capillary and venous volume responses across these conditions, these results offer support for a consistent total CBV-flow relationship typically assumed in blood oxygen-level dependent calibration techniques.

AB - Despite the different origins of cerebrovascular activity induced by neurogenic and nonneurogenic conditions, a standard assumption in functional studies is that the consequence on the vascular system will be mechanically similar. Using a recently developed arterial spin labeling method, we examined arterial blood volume, arterial-microvascular transit time, and cerebral blood flow (CBF) in the gray matter and in areas with large arterial vessels under hypercapnia, visual stimulation, and a combination of the two. Spatial heterogeneity in arterial reactivity was observed between conditions. During hypercapnia, large arterial volume changes contributed to CBF increase and further downstream, there were reductions in the gray matter transit time. These changes were not significant during visual stimulation, and during the combined condition they were moderated. These findings suggest distinct vascular mechanisms for large and small arterial segments that may be condition specific. However, the power relationships between gray matter arterial blood volume and CBF in hypercapnia (α0.690.24) and visual stimulation (α0.680.20) were similar. Assuming consistent capillary and venous volume responses across these conditions, these results offer support for a consistent total CBV-flow relationship typically assumed in blood oxygen-level dependent calibration techniques.

KW - cerebral blood flow

KW - cerebral hemodynamics

KW - experimental

KW - functional MRI

KW - neurophysiology

UR - http://www.scopus.com/inward/record.url?scp=79551634864&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79551634864&partnerID=8YFLogxK

U2 - 10.1038/jcbfm.2010.126

DO - 10.1038/jcbfm.2010.126

M3 - Article

VL - 31

SP - 560

EP - 571

JO - Journal of Cerebral Blood Flow and Metabolism

JF - Journal of Cerebral Blood Flow and Metabolism

SN - 0271-678X

IS - 2

ER -