Similar striatal D2/D3 dopamine receptor availability in adults with Tourette syndrome compared with healthy controls: A [11C]-(+)-PHNO and [11C]raclopride positron emission tomography imaging study

Elia Abi-Jaoude, Barbara Segura, Ignacio Obeso, Sang Soo Cho, Sylvain Houle, Anthony E. Lang, Pablo Rusjan, Paul Sandor, Antonio P. Strafella

Research output: Contribution to journalArticlepeer-review

Abstract

Pharmacological and anatomical evidence implicates striatal dopamine receptors in Tourette syndrome (TS). Nevertheless, results of positron emission tomography (PET) studies of the dopamine system in TS have been inconsistent. We investigated striatal D2/3 dopamine receptors in TS using the radioligands [11C]raclopride and [11C]-(+)-PHNO, an agonist that binds preferentially to D3 receptors, thus allowing higher sensitivity and measurement of receptors in a high affinity state. Eleven adults with TS and 11 matched healthy control (HC) participants underwent [11C]raclopride and [11C]-(+)-PHNO PET scans. General linear model was used for voxelwise contrasts of striatal binding potentials (BPND) between TS and HC participants. Analysis of variance was performed to investigate main effect of radioligand. In addition, BPND values were extracted for ventral, motor, and associative striatum. Finally, we examined the relationship between BPND measures and symptom severity in TS participants. Main effects analyses showed that [11C]-(+)-PHNO BPND was higher in ventral striatum, whereas [11C]raclopride BPND was higher in motor and associative striatum. There were no significant group differences between TS and HC. Furthermore, TS and HC participants had similar [11C]-(+)-PHNO and [11C]raclopride BPND in the three striatal subregions. Moreover, there was no significant correlation between BPND and symptom severity. TS and HC participants had similar striatal D2/3 receptor availability measures. These results challenge the assumption that striatal dopamine receptors have a major role in the pathophysiology of TS. Consistent with previous findings, [11C]-(+)-PHNO localized preferentially to ventral striatal, D3 receptor-rich regions, in contrast to [11C]raclopride, which localized preferentially in the dorsal striatum.

Original languageEnglish (US)
Pages (from-to)2592-2601
Number of pages10
JournalHuman Brain Mapping
Volume36
Issue number7
DOIs
StatePublished - Jul 1 2015

Keywords

  • Basal ganglia
  • Corpus striatum
  • Dopamine
  • Neostriatum
  • Positron-emission tomography
  • Raclopride
  • Receptors, dopamine
  • Receptors, dopamine D2
  • Tourette syndrome

ASJC Scopus subject areas

  • Anatomy
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Clinical Neurology

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