Similar hematologic changes in children receiving trimethoprim-sulfamethoxazole or amoxicillin for otitis media

Sandor Feldman, Margaret Doolittle, Lennie Lott, Paula Roberson, Walter T. Hughes

Research output: Contribution to journalArticle

Abstract

We report the hematologic changes in 90 black children who were randomized to receive a 10-day course of either trimethoprim-sulfamethoxazole (TMP-SMZ) or amoxicillin as therapy for acute otitis media. Absolute neutrophil counts <1500/mm3 developed at least once during the 23-day evaluation in 28 (57%) of the 49 children given TMP-SMZ and in 22 (54%) of the 41 who received amoxicillin. Incidence of leukopenia, thrombocytopenia, and anemia was negligible in both groups. Pancytopenia did not occur in any child. Absolute neutrophil counts had increased to >1500/mm3 by the end of the study period in all of the patients but six, whose recovery required an additional 1 to 63 days. Decreased neutrophil counts in antibiotic-treated subjects remained within the range of findings for healthy black children, suggesting that a count <1500/mm3 may be an inappropriate criterion for an adverse drug effect. Neither TMP-SMZ nor amoxicillin produced hematologic effects that would detract from their continued use in children with infections caused by antibiotic-susceptible organisms.

Original languageEnglish (US)
Pages (from-to)995-1000
Number of pages6
JournalThe Journal of pediatrics
Volume106
Issue number6
DOIs
StatePublished - Jun 1985

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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