Silicone gel and octamethylcyclotetrasiloxane [D4] enhances antibody production to bovine serum albumin in mice

J. Nicholson, S. L. Hill, C. G. Frondoza, N. R. Rose

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The hypothesis that components of the silicone breast implant potentiate antibody response is tested. The ability of silicone oil, silicone gel, and octamethylcyclotetrasiloxane [D4] to potentiate antibody production against a conventional test antigen bovine serum albumin (BSA) in mice is evaluated to determine the adjuvant effect of silicone products. Seventy A/J mice are used and tissue samples are analyzed by light microscopy and analysis of variance (ANOVA). Results showed that viscous silicone products potentiate antibody response. These silicone products can also exert a synergistic effect with other adjuvants.

Original languageEnglish (US)
Title of host publicationTransactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium
Editors Anon
PublisherSoc for Biomaterials
Pages304
Number of pages1
Volume1
StatePublished - 1996
EventProceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2) - Toronto, Can
Duration: May 29 1996Jun 2 1996

Other

OtherProceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2)
CityToronto, Can
Period5/29/966/2/96

Fingerprint

Silicone Gels
Silicones
Bovine Serum Albumin
Antibodies
Gels
Silicone Oils
Analysis of variance (ANOVA)
Optical microscopy
Tissue
Antigens
octamethylcyclotetrasiloxane

ASJC Scopus subject areas

  • Materials Science(all)

Cite this

Nicholson, J., Hill, S. L., Frondoza, C. G., & Rose, N. R. (1996). Silicone gel and octamethylcyclotetrasiloxane [D4] enhances antibody production to bovine serum albumin in mice. In Anon (Ed.), Transactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium (Vol. 1, pp. 304). Soc for Biomaterials.

Silicone gel and octamethylcyclotetrasiloxane [D4] enhances antibody production to bovine serum albumin in mice. / Nicholson, J.; Hill, S. L.; Frondoza, C. G.; Rose, N. R.

Transactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium. ed. / Anon. Vol. 1 Soc for Biomaterials, 1996. p. 304.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Nicholson, J, Hill, SL, Frondoza, CG & Rose, NR 1996, Silicone gel and octamethylcyclotetrasiloxane [D4] enhances antibody production to bovine serum albumin in mice. in Anon (ed.), Transactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium. vol. 1, Soc for Biomaterials, pp. 304, Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2), Toronto, Can, 5/29/96.
Nicholson J, Hill SL, Frondoza CG, Rose NR. Silicone gel and octamethylcyclotetrasiloxane [D4] enhances antibody production to bovine serum albumin in mice. In Anon, editor, Transactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium. Vol. 1. Soc for Biomaterials. 1996. p. 304
Nicholson, J. ; Hill, S. L. ; Frondoza, C. G. ; Rose, N. R. / Silicone gel and octamethylcyclotetrasiloxane [D4] enhances antibody production to bovine serum albumin in mice. Transactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium. editor / Anon. Vol. 1 Soc for Biomaterials, 1996. pp. 304
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