Silicone gel and octamethylcyclotetrasiloxane [D4] enhances antibody production to bovine serum albumin in mice

J. Nicholson, S. L. Hill, C. G. Frondoza, N. R. Rose

Research output: Contribution to conferencePaperpeer-review

Abstract

The hypothesis that components of the silicone breast implant potentiate antibody response is tested. The ability of silicone oil, silicone gel, and octamethylcyclotetrasiloxane [D4] to potentiate antibody production against a conventional test antigen bovine serum albumin (BSA) in mice is evaluated to determine the adjuvant effect of silicone products. Seventy A/J mice are used and tissue samples are analyzed by light microscopy and analysis of variance (ANOVA). Results showed that viscous silicone products potentiate antibody response. These silicone products can also exert a synergistic effect with other adjuvants.

Original languageEnglish (US)
Number of pages1
StatePublished - Dec 1 1996
EventProceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2) - Toronto, Can
Duration: May 29 1996Jun 2 1996

Other

OtherProceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2)
CityToronto, Can
Period5/29/966/2/96

ASJC Scopus subject areas

  • Materials Science(all)

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