Silane surface modification for improved bioadhesion of esophageal stents

Mert Karakoy, Evin Gultepe, Shivendra Pandey, Mouen A. Khashab, David H. Gracias

Research output: Contribution to journalArticle

Abstract

Stent migration occurs in 10-40% of patients who undergo placement of esophageal stents, with higher migration rates seen in those treated for benign esophageal disorders. This remains a major drawback of esophageal stent therapy. In this paper, we propose a new surface modification method to increase the adhesion between self-expandable metallic stents (SEMS) and tissue while preserving their removability. Taking advantage of the well-known affinity between epoxide and amine terminated silane coupling agents with amine and carboxyl groups that are abundant in proteins and related molecules in the human body; we modified the surfaces of silicone coated esophageal SEMS with these adhesive self-assembled monolayers (SAMs). We utilized vapor phase silanization to modify the surfaces of different substrates including PDMS strips and SEMS, and measured the force required to slide these substrates on a tissue piece. Our results suggest that surface modification of esophageal SEMS via covalent attachment of protein-binding coupling agents improves adhesion to tissue and could offer a solution to reduce SEMS migration while preserving their removability.

Original languageEnglish (US)
Pages (from-to)684-689
Number of pages6
JournalApplied Surface Science
Volume311
DOIs
StatePublished - Aug 30 2014

Keywords

  • Coating
  • Gastrointestinal
  • Proteins
  • Pull-force
  • Self-assembled monolayer

ASJC Scopus subject areas

  • Chemistry(all)
  • Condensed Matter Physics
  • Physics and Astronomy(all)
  • Surfaces and Interfaces
  • Surfaces, Coatings and Films

Fingerprint Dive into the research topics of 'Silane surface modification for improved bioadhesion of esophageal stents'. Together they form a unique fingerprint.

  • Cite this