Significant linkage to compulsive hoarding on chromosome 14 in families with obsessive-compulsive disorder: Results from the OCD collaborative genetics study

Jack Samuels, Yao Shugart Yin, Marco A. Grados, Virginia L. Willour, O. Joseph Bienvenu, Benjamin D. Greenberg, James A. Knowles, James T. McCracken, Scott L. Rauch, Dennis L. Murphy, Ying Wang, Anthony Pinto, Abby J. Fyer, John Piacentini, David L. Pauls, Bernadette Cullen, Steven A. Rasmussen, Rudolf Hoehn-Saric, David Valle, Kung Yee LiangMark A. Riddle, Gerald Nestadt

Research output: Contribution to journalArticle

Abstract

Objective: Individuals with obsessive-compulsive disorder (OCD) who have compulsive hoarding behavior are clinically different from other OCD-affected individuals. The objective of this study was to determine whether there are chromosomal regions specifically linked to compulsive hoarding behavior in families with obsessive-compulsive disorder. Methods: The authors used multipoint allele-sharing methods to assess for linkage in 219 multiplex OCD families collected as part of the OCD Collaborative Genetics Study. The authors treated compulsive hoarding as the phenotype of interest and also stratified families into those with and without two or more relatives affected with compulsive hoarding. Results: Using compulsive hoarding as the phenotype, there was suggestive linkage to chromosome 14 at marker D14S588 (Kong and Cox logarithm of the odds ratio [LOD] [KACall=2.9]). In families with two or more hoarding relatives, there was significant linkage of OCD to chromosome 14 at marker C14S1937 (KACall=3.7), whereas in families with fewer than two hoarding relatives, there was suggestive linkage to chromosome 3 at marker D3S2398 (KACall=2.9). Conclusions: The findings suggest that a region on chromosome 14 is linked with compulsive hoarding behavior in families with OCD.

Original languageEnglish (US)
Pages (from-to)493-499
Number of pages7
JournalAmerican Journal of Psychiatry
Volume164
Issue number3
DOIs
StatePublished - Mar 2007

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Chromosomes, Human, Pair 14
Obsessive-Compulsive Disorder
Compulsive Behavior
Phenotype
Chromosomes, Human, Pair 3
Hoarding
Alleles
Odds Ratio

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Significant linkage to compulsive hoarding on chromosome 14 in families with obsessive-compulsive disorder : Results from the OCD collaborative genetics study. / Samuels, Jack; Yin, Yao Shugart; Grados, Marco A.; Willour, Virginia L.; Bienvenu, O. Joseph; Greenberg, Benjamin D.; Knowles, James A.; McCracken, James T.; Rauch, Scott L.; Murphy, Dennis L.; Wang, Ying; Pinto, Anthony; Fyer, Abby J.; Piacentini, John; Pauls, David L.; Cullen, Bernadette; Rasmussen, Steven A.; Hoehn-Saric, Rudolf; Valle, David; Liang, Kung Yee; Riddle, Mark A.; Nestadt, Gerald.

In: American Journal of Psychiatry, Vol. 164, No. 3, 03.2007, p. 493-499.

Research output: Contribution to journalArticle

Samuels, Jack ; Yin, Yao Shugart ; Grados, Marco A. ; Willour, Virginia L. ; Bienvenu, O. Joseph ; Greenberg, Benjamin D. ; Knowles, James A. ; McCracken, James T. ; Rauch, Scott L. ; Murphy, Dennis L. ; Wang, Ying ; Pinto, Anthony ; Fyer, Abby J. ; Piacentini, John ; Pauls, David L. ; Cullen, Bernadette ; Rasmussen, Steven A. ; Hoehn-Saric, Rudolf ; Valle, David ; Liang, Kung Yee ; Riddle, Mark A. ; Nestadt, Gerald. / Significant linkage to compulsive hoarding on chromosome 14 in families with obsessive-compulsive disorder : Results from the OCD collaborative genetics study. In: American Journal of Psychiatry. 2007 ; Vol. 164, No. 3. pp. 493-499.
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abstract = "Objective: Individuals with obsessive-compulsive disorder (OCD) who have compulsive hoarding behavior are clinically different from other OCD-affected individuals. The objective of this study was to determine whether there are chromosomal regions specifically linked to compulsive hoarding behavior in families with obsessive-compulsive disorder. Methods: The authors used multipoint allele-sharing methods to assess for linkage in 219 multiplex OCD families collected as part of the OCD Collaborative Genetics Study. The authors treated compulsive hoarding as the phenotype of interest and also stratified families into those with and without two or more relatives affected with compulsive hoarding. Results: Using compulsive hoarding as the phenotype, there was suggestive linkage to chromosome 14 at marker D14S588 (Kong and Cox logarithm of the odds ratio [LOD] [KACall=2.9]). In families with two or more hoarding relatives, there was significant linkage of OCD to chromosome 14 at marker C14S1937 (KACall=3.7), whereas in families with fewer than two hoarding relatives, there was suggestive linkage to chromosome 3 at marker D3S2398 (KACall=2.9). Conclusions: The findings suggest that a region on chromosome 14 is linked with compulsive hoarding behavior in families with OCD.",
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AU - Hoehn-Saric, Rudolf

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