Significant correlation between matrix metalloproteinase activity and tumor necrosis factor-α in salivary extravasation mucoceles

Mohammad Obaidul Hoque, Masayuki Azuma, Mitsunobu Sato

Research output: Contribution to journalArticlepeer-review

Abstract

We examined the matrix metalloproteinase (MMP) activity and tumor necrosis factor (TNF)-α in luminal fluid of 18 extravasation mucoceles and in saliva from Wharton's duct of five patients by means of gelatin zymography and enzyme immunoassay, respectively. The luminal fluid showed a high level of MMP activity compared with the saliva. Quantitative determination by enzyme immunoassay revealed that the luminal fluid contained higher levels of TNF-α than the saliva. In addition, the amount of TNF-α in luminal fluid exhibited a direct correlation with MMP activity estimated by densitometric analysis of gelatin zymograms. Since TNF-α stimulates the production of MMPs from cells such as fibroblasts, these results suggest that TNF-α is one of the causal molecules that enhance the accumulation of proteolytic enzymes in luminal fluid of mucoceles.

Original languageEnglish (US)
Pages (from-to)30-33
Number of pages4
JournalJournal of Oral Pathology and Medicine
Volume27
Issue number1
DOIs
StatePublished - Jan 1998
Externally publishedYes

Keywords

  • MMPs
  • Mucocele
  • TNF-α

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Oral Surgery
  • Otorhinolaryngology
  • Cancer Research
  • Periodontics

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