TY - JOUR
T1 - Significant Changes in HIV Antigen Level in the Serum of Patients Treated with Azidothymidine
AU - Chaisson, Richard E.
AU - Allain, Jean Pierre
AU - Leuther, Michael
AU - Volberding, Paul A.
PY - 1986/12/18
Y1 - 1986/12/18
N2 - To the Editor: Antiviral therapy against the human immunodeficiency virus (HIV), the causative agent of the acquired immunodeficiency syndrome (AIDS), can be assessed by clinical, immunologic, and virologic measures.1 The use of retroviral isolation from peripheral-blood mononuclear leukocytes of patients treated with antiviral agents may be limited by the time requirements, difficulty, and expense of most culture assays.2 It has recently been shown that HIV core antigen can be detected in the serum of patients with AIDS and that increases in the concentration of this antigen may correlate with clinical deterioration.3 We report here the results of testing for HIV.
AB - To the Editor: Antiviral therapy against the human immunodeficiency virus (HIV), the causative agent of the acquired immunodeficiency syndrome (AIDS), can be assessed by clinical, immunologic, and virologic measures.1 The use of retroviral isolation from peripheral-blood mononuclear leukocytes of patients treated with antiviral agents may be limited by the time requirements, difficulty, and expense of most culture assays.2 It has recently been shown that HIV core antigen can be detected in the serum of patients with AIDS and that increases in the concentration of this antigen may correlate with clinical deterioration.3 We report here the results of testing for HIV.
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U2 - 10.1056/NEJM198612183152511
DO - 10.1056/NEJM198612183152511
M3 - Letter
C2 - 3466034
AN - SCOPUS:0022921524
SN - 0028-4793
VL - 315
SP - 1610
EP - 1611
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 25
ER -