Significance of preoperative PSA velocity in men with low serum PSA and normal DRE


Objectives: A PSA velocity (PSAV)>0.35 ng/ml/year approximately 10-15 years prior to diagnosis is associated with a greater risk of lethal prostate cancer. Some have recommended that a PSAV>0.35 ng/ml/year should prompt a prostate biopsy in men with a low serum PSA (0. 35 ng/ml/year in 124 (36.6%) of 339 men. Although there were no significant differences in clinico-pathological characteristics based upon PSAV, men with a PSAV>0.35 ng/ml/year were significantly more likely to experience biochemical progression after RP at a median follow-up of 4 years (P = 0.022). Conclusions: In this low-risk population with a preoperative PSA 0.35 ng/ml/year. Physicians should carefully monitor men with a preoperative PSA>0.35 ng/ml/year as they are at increased risk of biochemical progression following RP.

Original languageEnglish (US)
Pages (from-to)11-14
Number of pages4
JournalWorld Journal of Urology
Issue number1
Publication statusPublished - 2011
Externally publishedYes



  • Gleason score
  • Pathologic stage
  • Prostate cancer
  • PSA
  • PSAV
  • Radical prostatectomy

ASJC Scopus subject areas

  • Urology

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