Most of the time, transplantation rejection is immunologically mediated. Both T cells and circulating antibodies are induced against allografts and xenografts. Antibodies produced are responsible for hyperacute rejections, T cells are mainly responsible for rejection of most other tissues. The most important transplantation antigens, which cause rapid rejection of the allograft, are found on cell membranes and are encoded by genes in the major histocompatibility complex (MHC) which is known as HLA in humans and H-2 in mice. HLA helps in discriminating between self and non-self. The approaches to enhance graft survival are gaining acceptance and wide use in human tissue and organ transplantation. Various mechanisms involved in allograft rejection are discussed in detail in this review.
|Original language||English (US)|
|Number of pages||15|
|State||Published - Apr 25 2000|
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