Significance of human leukocyte antigens in immunobiology of renal transplantation

Suraksha Agrawal, Avneesh Kumar Singh, Uddalak Bharadwaj

Research output: Contribution to journalReview articlepeer-review

Abstract

Most of the time, transplantation rejection is immunologically mediated. Both T cells and circulating antibodies are induced against allografts and xenografts. Antibodies produced are responsible for hyperacute rejections, T cells are mainly responsible for rejection of most other tissues. The most important transplantation antigens, which cause rapid rejection of the allograft, are found on cell membranes and are encoded by genes in the major histocompatibility complex (MHC) which is known as HLA in humans and H-2 in mice. HLA helps in discriminating between self and non-self. The approaches to enhance graft survival are gaining acceptance and wide use in human tissue and organ transplantation. Various mechanisms involved in allograft rejection are discussed in detail in this review.

Original languageEnglish (US)
Pages (from-to)974-988
Number of pages15
JournalCurrent Science
Volume78
Issue number8
StatePublished - Apr 25 2000
Externally publishedYes

ASJC Scopus subject areas

  • General

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