Significance of 99mTc-sulfur colloid splenic image in malignant melanoma

R. A. Berjian, K. L. Parthasarathy, M. S. Didolkar, S. P. Bakshi, R. H. Moore

Research output: Contribution to journalArticle

Abstract

To evaluate the clinical significance of 99m Tc-sulfur-colloid (TcSC) spleen scan findings in patients with malignant melanoma, a retrospective study was undertaken. Eighty-one patients with histologically proven malignant melanoma who received treatment in Roswell Park during a 5 yr period were included in this study. The scans were analyzed for spleen size, differential uptake of the tracer in liver and spleen, and for the presence of metastases in these two organs. These data were compared with stage of disease, survival, and autopsy findings. Significant correlation was found between the splenic size as measured on the scintiscan and at autopsy examination. The spleen size was found to be normal in 92% of the patients in early melanoma. The median survival of patients who had a normal-sized spleen by scan criteria was found to be longer than those who had splenomegaly. No significant difference in survival was noted between the patients with and without augmented splenic uptake of TcSC. Only a small number (17.7%) of patients with augmented splenic uptake had splenic metastases; hence, the possible role of immunological factors was considered.

Original languageEnglish (US)
Pages (from-to)53-60
Number of pages8
JournalJournal of Surgical Oncology
Volume13
Issue number1
DOIs
StatePublished - 1980
Externally publishedYes

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Colloids
Sulfur
Melanoma
Spleen
Survival
Autopsy
Technetium Tc 99m Sulfur Colloid
Neoplasm Metastasis
Splenomegaly
Immunologic Factors
Retrospective Studies
Liver

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Berjian, R. A., Parthasarathy, K. L., Didolkar, M. S., Bakshi, S. P., & Moore, R. H. (1980). Significance of 99mTc-sulfur colloid splenic image in malignant melanoma. Journal of Surgical Oncology, 13(1), 53-60. https://doi.org/10.1002/jso.2930130109

Significance of 99mTc-sulfur colloid splenic image in malignant melanoma. / Berjian, R. A.; Parthasarathy, K. L.; Didolkar, M. S.; Bakshi, S. P.; Moore, R. H.

In: Journal of Surgical Oncology, Vol. 13, No. 1, 1980, p. 53-60.

Research output: Contribution to journalArticle

Berjian, RA, Parthasarathy, KL, Didolkar, MS, Bakshi, SP & Moore, RH 1980, 'Significance of 99mTc-sulfur colloid splenic image in malignant melanoma', Journal of Surgical Oncology, vol. 13, no. 1, pp. 53-60. https://doi.org/10.1002/jso.2930130109
Berjian, R. A. ; Parthasarathy, K. L. ; Didolkar, M. S. ; Bakshi, S. P. ; Moore, R. H. / Significance of 99mTc-sulfur colloid splenic image in malignant melanoma. In: Journal of Surgical Oncology. 1980 ; Vol. 13, No. 1. pp. 53-60.
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