Signaling through chemoattractant receptors in Dictyostelium

Mei Yu Chen, Robert H. Insall, Peter N. Devreotes

Research output: Contribution to journalReview articlepeer-review


Dictyostelium discoideum displays chemoattractant-directed cell migration typical of many higher cell types. Signaling through chemoattractant receptors involves a standard G-protein-linked pathway. Genetic analysis has distinguished essential and dispensable components and demonstrated that some signaling events are independent of G proteins. Genetic analysis has also led to the identification of additional genes involved in chemosensory transduction. Further studies on the newly discovered components and pathways should help in elucidating the molecular mechanisms of eukaryotic chemotaxis.

Original languageEnglish (US)
Pages (from-to)52-57
Number of pages6
JournalTrends in Genetics
Issue number2
StatePublished - Feb 1996

ASJC Scopus subject areas

  • Genetics


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