Signaling the pathway to regeneration

William D. Snider, Feng Quan Zhou, Jian Zhong, Annette Markus

Research output: Contribution to journalReview articlepeer-review

125 Scopus citations


Robust axon regeneration occurs after peripheral nerve injury through coordinated activation of a genetic program and local intracellular signaling cascades. Although regeneration-associated genes are being identified with increasing frequency, most aspects of regeneration-associated intracellular signaling remain poorly understood. Two independent studies now report that upregulation of cAMP is a component of the PNS regeneration program that can be exploited to enhance axon regeneration through the normally inhibitory CNS environment.

Original languageEnglish (US)
Pages (from-to)13-16
Number of pages4
Issue number1
StatePublished - Jul 3 2002
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)


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