Abstract
Robust axon regeneration occurs after peripheral nerve injury through coordinated activation of a genetic program and local intracellular signaling cascades. Although regeneration-associated genes are being identified with increasing frequency, most aspects of regeneration-associated intracellular signaling remain poorly understood. Two independent studies now report that upregulation of cAMP is a component of the PNS regeneration program that can be exploited to enhance axon regeneration through the normally inhibitory CNS environment.
Original language | English (US) |
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Pages (from-to) | 13-16 |
Number of pages | 4 |
Journal | Neuron |
Volume | 35 |
Issue number | 1 |
DOIs | |
State | Published - Jul 3 2002 |
Externally published | Yes |
ASJC Scopus subject areas
- General Neuroscience