Signaling pathways that regulate axon regeneration

Saijilafu, Bo Yin Zhang, Feng Quan Zhou

Research output: Contribution to journalReview articlepeer-review

Abstract

Neurons in the mammalian central nervous system (CNS) cannot regenerate axons after injury. in contrast, neurons in the mammalian peripheral nervous system and in some non-mammalian models, such as C. elegans and Drosophila, are able to regrow axons. Understanding the molecular mechanisms by which these neurons support axon regeneration will help us find ways to enhance mammalian CNS axon regeneration. Here, recent studies in which signaling pathways regulating naturally-occurring axon regeneration that have been identified are reviewed, focusing on how these pathways control gene expression and growth-cone function during axon regeneration.

Original languageEnglish (US)
Pages (from-to)411-420
Number of pages10
JournalNeuroscience Bulletin
Volume29
Issue number4
DOIs
StatePublished - Aug 2013

Keywords

  • axon regeneration
  • axonal growth
  • signal transduction

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology

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